SynthesisMedicine2018
Stapled side-to-side anastomosis might be benefit in intestinal resection for Crohn's disease: A systematic review and network meta-analysis.
Synthesis in Medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 4 syntheses or guidelines pooled it, 73 citations in OpenAlex.
- Anastomotic configurations and early endoscopic recurrence following ileocolonic resection in Crohn's disease: systematic review and meta-analysis.International journal of colorectal disease · 2026Pooled it
- Surgical features to reduce anastomotic recurrence of Crohn's disease that requires reoperation: a systematic review.Surgery today · 2022Pooled it
- Stapled versus hand-sewn intestinal anastomosis in pediatric patients: a systematic review and meta-analysis.BMC pediatrics · 2021Pooled it
- Stapled versus handsewn methods for ileocolic anastomoses.Techniques in coloproctology · 2019Pooled it
- Objective recovery time with end-to-side versus side-to-side anastomosis after laparoscopic right hemicolectomy for colon cancer: a randomized controlled trial.Surgical endoscopy · 2022Trial
- Postoperative ileus as a surgical challenge: comparative outcomes of end-to-end and side-to-side ileal anastomosis in radical cystectomy.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2026Article
- Comparative anastomotic configurations and disease recurrence rates of robotic vs. laparoscopic primary ileocolonic resection for Crohn's disease.Surgical endoscopy · 2026Article
- Postoperative Recurrence in Crohn's Disease: Pathophysiology, Risk Stratification, and Management Strategies.Journal of clinical medicine · 2025Review
- Recurrent Ulceration and Disease at the Ileocolonic Anastomosis in Crohn's Disease: Etiology, Prevention, and Management, a Review Article.Journal of clinical medicine · 2025Review
- Precision grading of surgical strategies for small bowel Crohn's disease: An R0-R3 individualized framework based on lesion severity and functional preservation.Intractable & rare diseases research · 2025Article
- Bowel Resection Margins in Crohn's Disease: Do They Matter?Clinics in colon and rectal surgery · 2025Review
- Anastomosis after Bowel Resection for Crohn's Disease: State of the Art Review.Clinics in colon and rectal surgery · 2025Review
- Surgery time for stenosed Crohn's disease: Case report.International journal of surgery case reports · 2025Article
- Management of inflammatory bowel disease in the emergency setting: the MIBODI international survey and evidence-based practices.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2024Article
- A Comparative Study of Hand-Sewn and Stapled Anastomosis in Gastrointestinal Surgeries.Cureus · 2024Article
- Stapled versus hand-sewn anastomoses after bowel resection in patients with crohn disease.BMC surgery · 2024Article
- The Reduction of Anastomosis-Related Morbidity Using the Kono-S Anastomosis in Patients with Crohn's Disease: A Meta-Analysis.Journal of clinical medicine · 2024Review
- Management of Post-Operative Crohn's Disease: Knowns and Unknowns.Journal of clinical medicine · 2024Review
- Kono-S anastomosis in Crohn's disease: initial experience in pediatric patients.Pediatric surgery international · 2024Article
- Adhesive cryogel particles for bridging confined and irregular tissue defects.Military Medical Research · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimIntestinal anastomosis is an essential step in the intestinal resection in patients with Crohn's disease (CD). Anastomotic configuration such as handsewn end-to-end anastomosis (HEEA), stapled side-to-side anastomosis (SSSA) and so on may be a predictor of prognosis for postoperative CD patients. However, the association between anastomotic types and surgical outcomes are controversial. The aim of this review is to identify the optimal anastomosis for intestinal resection in patients with CD.
methodsClinical trials comparing anastomosis after intestinal resection in patients with CD were searched in the database of MEDLINE, EMBASE, and the Cochrane Library. Outcomes such as postoperative hospital stay, complications, mortality, recurrence, and reoperation were evaluated. Pairwise treatment effects were estimated through a random-effects network meta-analysis based on the frequency framework by using the STATA software and reported as the estimated summary effect for each comparison between the 2 treatments in the network with a 95% credible interval.
resultsA total of 1113 patients in 11 trials were included. In pair-wise comparisons between groups, for overall postoperative complications, SSSA showed a more probability of superiority to HEEA; for complications other than anastomotic leak, anastomotic leak, wound infection, postoperative hospital stay and mortality, there were no significant difference between groups; for clinical recurrence, SSSA showed a more probability of superiority to HEEA; for reoperation, SSSA showed a more probability of superiority to HEEA. The number of eligible randomized controlled trails (RCTs) was small, and more than half of the included trials were retrospective studies; selection bias may lead to a less power in this assessment; follow-up time between different groups was different, which may possibly have affected the interpretation of the analysis of long-term outcome.
conclusionBy comprehensive analyzing all the postoperative outcomes, SSSA appeared to be the optimal anastomotic strategy after intestinal resection for patients with CD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.