ReviewCurrent opinion in neurobiology2018
High-speed 3D imaging of cellular activity in the brain using axially-extended beams and light sheets.
Review in Current opinion in neurobiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- Optogenetic interrogation of the zebrafish lateral line reveals brain-wide neural circuits involved in pattern separation.iScience · 2025Article
- High content 3D imaging by dual-view oblique plane microscopy.PNAS nexus · 2025Article
- Nonlinear sound-sheet microscopy: Imaging opaque organs at the capillary and cellular scale.Science (New York, N.Y.) · 2025Article
- Article
- Multispectral imaging for characterizing autofluorescent tissues.Scientific reports · 2024Article
- Combined ion beam irradiation platform and 3D fluorescence microscope for cellular cancer research.Biomedical optics express · 2024Article
- Audiovisualization of real-time neuroimaging data.PloS one · 2024Article
- Neuromuscular basis ofProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Widefield imaging of rapid pan-cortical voltage dynamics with an indicator evolved for one-photon microscopy.Nature communications · 2023Article
- Recent advances in oblique plane microscopy.Nanophotonics (Berlin, Germany) · 2023Review
- High-speed light-sheet microscopy for the in-situ acquisition of volumetric histological images of living tissue.Nature biomedical engineering · 2022Article
- Neurophotonic tools for microscopic measurements and manipulation: status report.Neurophotonics · 2022Article
- Two-photon scanned light sheet fluorescence microscopy with axicon imaging for fast volumetric imaging.Journal of biomedical optics · 2021Article
- Emerging imaging methods to study whole-brain function in rodent models.Translational psychiatry · 2021Review
- Review of bio-optical imaging systems with a high space-bandwidth product.Advanced photonics · 2021Article
- Whole brain functional recordings at cellular resolution in zebrafish larvae with 3D scanning multiphoton microscopy.Scientific reports · 2021Article
- Voltage Imaging with a NIR-Absorbing Phosphine Oxide Rhodamine Voltage Reporter.Journal of the American Chemical Society · 2021Article
- Spatio-temporal parameters for optical probing of neuronal activity.Biophysical reviews · 2021Review
- Genetically Encoded Voltage Indicators.Advances in experimental medicine and biology · 2021Review
- Toward Community-Driven Big Open Brain Science: Open Big Data and Tools for Structure, Function, and Genetics.Annual review of neuroscience · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
As optical reporters and modulators of cellular activity have become increasingly sophisticated, the amount that can be learned about the brain via high-speed cellular imaging has increased dramatically. However, despite fervent innovation, point-scanning microscopy is facing a fundamental limit in achievable 3D imaging speeds and fields of view. A range of alternative approaches are emerging, some of which are moving away from point-scanning to use axially-extended beams or sheets of light, for example swept confocally aligned planar excitation (SCAPE) microscopy. These methods are proving effective for high-speed volumetric imaging of the nervous system of small organisms such as Drosophila (fruit fly) and D. Rerio (Zebrafish), and are showing promise for imaging activity in the living mammalian brain using both single and two-photon excitation. This article describes these approaches and presents a simple model that demonstrates key advantages of axially-extended illumination over point-scanning strategies for high-speed volumetric imaging, including longer integration times per voxel, improved photon efficiency and reduced photodamage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.