ArticleBiophysical journal2018
Partitioning and Enhanced Self-Assembly of Actin in Polypeptide Coacervates.
Article in Biophysical journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 105 citations in OpenAlex.
- Bottom-Up Coacervate-Based Artificial Cells: Integrating Cellular Hallmarks into Complex Life-Like Systems.Angewandte Chemie (International ed. in English) · 2026Review
- Article
- Computer Simulations Show That Liquid-Liquid Phase Separation Enhances Self-Assembly.ACS nano · 2025Article
- Enzymatic Reaction Network-Driven Polymerization-Induced Transient Coacervation.Angewandte Chemie (International ed. in English) · 2024Article
- Supramolecular fibrillation in coacervates and other confined systems towards biomimetic function.Communications chemistry · 2024Review
- The role of biomolecular condensates in protein aggregation.Nature reviews. Chemistry · 2024Review
- Did the exposure of coacervate droplets to rain make them the first stable protocells?Science advances · 2024Article
- Sequestration of Small Ions and Weak Acids and Bases by a Polyelectrolyte Complex Studied by Simulation and Experiment.Macromolecules · 2024Article
- Genome maintenance meets mechanobiology.Chromosoma · 2024Review
- Selective amide bond formation in redox-active coacervate protocells.Nature communications · 2023Article
- The interface of condensates of the hnRNPA1 low-complexity domain promotes formation of amyloid fibrils.Nature chemistry · 2023Article
- Self-assembly coupled to liquid-liquid phase separation.PLoS computational biology · 2023Article
- Liquid-like VASP condensates drive actin polymerization and dynamic bundling.Nature physics · 2023Article
- The Role of Liquid-Liquid Phase Separation in Actin Polymerization.International journal of molecular sciences · 2023Review
- Capturing coacervate formation and protein partition by molecular dynamics simulation.Chemical science · 2023Article
- Aggregation controlled by condensate rheology.Biophysical journal · 2023Article
- Biomolecular condensates can both accelerate and suppress aggregation of α-synuclein.Science advances · 2022Article
- Nucleation causes an actin network to fragment into multiple high-density domains.Biophysical journal · 2022Article
- Spatiotemporal control of signal-driven enzymatic reaction in artificial cell-like polymersomes.Nature communications · 2022Article
- Actinosomes: Condensate-Templated Containers for Engineering Synthetic Cells.ACS synthetic biology · 2022Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biomolecules exist and function in cellular microenvironments that control their spatial organization, local concentration, and biochemical reactivity. Due to the complexity of native cytoplasm, the development of artificial bioreactors and cellular mimics to compartmentalize, concentrate, and control the local physico-chemical properties is of great interest. Here, we employ self-assembling polypeptide coacervates to explore the partitioning of the ubiquitous cytoskeletal protein actin into liquid polymer-rich droplets. We find that actin spontaneously partitions into coacervate droplets and is enriched by up to ∼30-fold. Actin polymerizes into micrometer-long filaments and, in contrast to the globular protein BSA, these filaments localize predominately to the droplet periphery. We observe up to a 50-fold enhancement in the actin filament assembly rate inside coacervate droplets, consistent with the enrichment of actin within the coacervate phase. Together these results suggest that coacervates can serve as a versatile platform in which to localize and enrich biomolecules to study their reactivity in physiological environments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.