Evidence map›Paper›PMID 29642027›Full record

ArticleBiophysical journal2018

Modeling the Early Stages of Phase Separation in Disordered Elastin-like Proteins.

Yue Zhang, Valeria Zai-Rose, Cody J Price, Nicholas A Ezzell, Gene L Bidwell, John J Correia, Nicholas C Fitzkee

Open access · bronzeAbstract read
In one paragraph

Article in Biophysical journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Yue ZhangDepartment of Chemistry, Mississippi State University, Mississippi State, Mississippi.
Valeria Zai-RoseDepartment of Biochemistry, University of Mississippi Medical Center, Jackson, Mississippi.
Cody J PriceDepartment of Chemistry, Mississippi State University, Mississippi State, Mississippi.
Nicholas A EzzellDepartment of Chemistry, Mississippi State University, Mississippi State, Mississippi.
Gene L BidwellDepartment of Biochemistry, University of Mississippi Medical Center, Jackson, Mississippi.
John J CorreiaDepartment of Biochemistry, University of Mississippi Medical Center, Jackson, Mississippi.
Nicholas C FitzkeeDepartment of Chemistry, Mississippi State University, Mississippi State, Mississippi. Electronic address: nfitzkee@chemistry.msstate.edu.
Mississippi State University · USUniversity of Mississippi Medical Center · US

Funding

A Novel Protein Delivery System for Therapy of PreeclampsiaR01HL121527 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI BIDWELL, GENE LEFLORE · 2014 to 2023
$4.1M
Functionalized Gold Nanoparticles: Understanding the Mechanism of Protein BindingR15GM113152 · NIGMS · MISSISSIPPI STATE UNIVERSITY · PI FITZKEE, NICHOLAS C · 2015 to 2015
$339k
NHLBI NIH HHS R01 HL121527NIGMS NIH HHS R15 GM113152
6 · The paper itself

Abstract

Elastin-like proteins (ELPs) are known to undergo liquid-liquid phase separation reversibly above a concentration-dependent transition temperature. Previous studies suggested that, as temperature increases, ELPs experience an increased propensity for type II β-turns. However, how the ELPs behave below the phase transition temperature itself is still elusive. Here, we investigate the importance of β-turn formation during the early stages of ELP self-association. We examined the behavior of two ELPs, a 150-repeat construct that had been investigated previously (ELP[V

Indexed as

Models, MolecularAmino Acid SequenceElastinHydrodynamicsHydrophobic and Hydrophilic InteractionsMonte Carlo MethodProtein MultimerizationProtein Structure, SecondarySolventsThermodynamicsElastinSolvents

Identifiers

PMID29642027
PMCPMC5954566
OpenAlexW2797783923

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.