Evidence map›Paper›PMID 29641981›Full record

ArticleNanomedicine : nanotechnology, biology, and medicine2018

Biodistribution and PET imaging of 89-zirconium labeled cerium oxide nanoparticles synthesized with several surface coatings.

Philip Reed McDonagh, Gobalakrishnan Sundaresan, Likun Yang, Minghao Sun, Ross Mikkelsen, Jamal Zweit

Abstract read
In one paragraph

Article in Nanomedicine : nanotechnology, biology, and medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Article
  3. Recent nanotheranostic approaches in cancer research.Clinical and experimental medicine · 2024
    Review
  4. Metal-Based Nanoparticles for Cardiovascular Diseases.International journal of molecular sciences · 2024
    Review
  5. Article
  6. Article
  7. Preclinical PET and MR Evaluation ofNanomaterials (Basel, Switzerland) · 2022
    Article
  8. Image-guided mathematical modeling for pharmacological evaluation of nanomaterials and monoclonal antibodies.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2020
    Review
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Philip Reed McDonaghVirginia Commonwealth University, Center for Molecular Imaging, P.O. Box 980031, Richmond, VA, USA. Electronic address: mcdonaghpr@vcu.edu.
Gobalakrishnan SundaresanVirginia Commonwealth University, Center for Molecular Imaging, P.O. Box 980031, Richmond, VA, USA.
Likun YangVirginia Commonwealth University, Center for Molecular Imaging, P.O. Box 980031, Richmond, VA, USA.
Minghao SunVirginia Commonwealth University, Center for Molecular Imaging, P.O. Box 980031, Richmond, VA, USA.
Ross MikkelsenVirginia Commonwealth University, Department of Radiation Oncology, P.O. Box 980058, Richmond, Virginia, USA.
Jamal ZweitVirginia Commonwealth University, Center for Molecular Imaging, P.O. Box 980031, Richmond, VA, USA; Virginia Commonwealth University, Department of Radiation Oncology, P.O. Box 980058, Richmond, Virginia, USA.

Funding

Molecular Imaging to Study Radio-Protection by Cerium Oxide NanoparticlesF30CA186613 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI MCDONAGH, PHILIP REED · 2015 to 2016
$70k
NCI NIH HHS F30 CA186613
6 · The paper itself

Abstract

Cerium oxide nanoparticles (CONPs) have unique surface chemistry allowing catalyst-like antioxidant properties, and are being investigated for several disease indications in medicine. Studies have utilized surface modified CONPs toward this application, but have been lacking in comprehensive biodistribution and pharmacokinetic data and a direct comparison to uncoated CONPs. We developed an enhanced single-pot synthesis of several coated CONPs and an efficient intrinsic core labeling of CONPs with the clinical PET isotope, zirconium-89, allowing detailed PET imaging and ex vivo biodistribution. All coated [

Indexed as

Acrylic ResinsAntioxidantsCeriumNanoparticlesPositron-Emission TomographyRadioisotopesZirconiumAcrylic ResinsAntioxidantscarbopol 940ceric oxideCeriumRadioisotopesZirconiumZirconium-89AntioxidantBiodistributionCerium oxide nanoparticlesPET imagingSurface coatingZirconium-89

Identifiers

PMID29641981
PMCPMC6175665

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.