ArticleCurrent eye research2018
In Vivo Imaging of the Retina, Choroid, and Optic Nerve Head in Guinea Pigs.
Article in Current eye research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- Normative assessment of corneal thickness and iridocorneal angle parameters in guinea pigs (Cavia porcellus) using spectral-domain optical coherence tomography.Veterinary research communications · 2026Article
- Refractive Development and Choroidal Vascularity in the Form-Deprivation Pigmented Rabbit Model.Translational vision science & technology · 2025Article
- Inhibition of lens-induced myopia in guinea pigs using a far-induced infrared ray material.Frontiers in medicine · 2025Article
- Morphological and vascular evidence of glaucomatous damage in myopic guinea pigs with scleral crosslinking.Scientific reports · 2024Article
- Suprachoroidal Delivery in Rats and Guinea Pigs Using a High-Precision Microneedle Injector.Translational vision science & technology · 2023Article
- Morphological and Morphometric Analysis of Canine Choroidal Layers Using Spectral Domain Optical Coherence Tomography.International journal of environmental research and public health · 2023Article
- Scleral Cross-Linking in Form-Deprivation Myopic Guinea Pig Eyes Leads to Glaucomatous Changes.Investigative ophthalmology & visual science · 2022Article
- Comparing low-coherence interferometry and A-scan ultrasonography in measuring ocular axial dimensions in young rhesus monkeys.Experimental eye research · 2022Article
- Morphological and vascular characteristics of the optic nerve head of normal guinea pigs.Scientific reports · 2022Article
- Electroacupuncture Improves Choroidal Blood Flow to Inhibit the Development of Lens-Induced Myopia in Guinea Pigs.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Visual function in guinea pigs: behavior and electrophysiology.Clinical & experimental optometry · 2021Article
- Article
- Retinal ganglion cell ablation in guinea pigs.Experimental eye research · 2021Article
- The optic nerve head, lamina cribrosa, and nerve fiber layer in non-myopic and myopic children.Experimental eye research · 2020Article
- Bruch's Membrane Thickness and Retinal Pigment Epithelium Cell Density in Experimental Axial Elongation.Scientific reports · 2019Article
- Matching the LenStar optical biometer to A-Scan ultrasonography for use in small animal eyes with application to tree shrews.Experimental eye research · 2019Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
purposeGuinea pigs are increasingly being used as a model of myopia, and may also represent a novel model of glaucoma. Here, optical coherence tomography (OCT) imaging was performed in guinea pigs. In vivo measurements of retinal, choroidal, and optic nerve head parameters were compared with histology, and repeatability and interocular variations were assessed.
methodsOCT imaging and histology were performed on adult guinea pigs (n = 9). Using a custom program in MATLAB, total retina, ganglion cell/nerve fiber layer (GC/NFL), outer retina, and choroid thicknesses were determined. Additionally, Bruch's membrane opening (BMO) area and diameter, and minimum rim width were calculated. Intraobserver, interocular, and intersession coefficients of variation (CV) and intraclass correlation coefficients (ICC) were assessed.
resultsRetina, GC/NFL, outer retina and choroid thicknesses from in vivo OCT imaging were 147.7 ± 5.8 μm, 59.2 ± 4.5 μm, 72.4 ± 2.4 μm, and 64.8 ± 11.6 μm, respectively. Interocular CV ranged from 1.8% to 11% (paired t-test, p = 0.16 to 0.81), and intersession CV ranged from 1.1% to 5.6% (p = 0.12 to 0.82), with the choroid showing the greatest variability. BMO area was 0.192 ± 0.023 mm
conclusionIn vivo OCT imaging and quantification of guinea pig retina and optic nerve head parameters were repeatable and similar between eyes of the same animal. In vivo visibility of retinal cell layers correlated well with histological images. ABBREVIATIONS: optic nerve head (ONH), retinal ganglion cell (RGC), spectral domain optical coherence tomography (SD-OCT), enhanced depth imaging (EDI), minimum rim width (MRW), hematoxylin and eosin (H & E).
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Registered trials
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