ArticleJournal of toxicology and environmental health. Part A2018
Arsenic association with circulating oxidized low-density lipoprotein in a Native American community.
Article in Journal of toxicology and environmental health. Part A, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
- Characterization of Carcinogenic and Non-Carcinogenic Metal(loid)s in Water Within a Uranium-Mining-Impacted Region in Northwestern New Mexico, USA.International journal of environmental research and public health · 2026Article
- Chronic arsenic exposure and cardiometabolic biomarkers in adolescents in the MINIMat longitudinal study.Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2025Article
- Advancements in heavy metal detection using microneedle array technology.Toxicology mechanisms and methods · 2025Article
- Metal mixture exposures and multiplexed autoantibody screening in Navajo communities exposed to uranium mine wastes.Journal of translational autoimmunity · 2023Article
- Article
- Environmental and occupational health on the Navajo Nation: a scoping review.Reviews on environmental health · 2022Article
- Prenatal Metal Exposures and Infants' Developmental Outcomes in a Navajo Population.International journal of environmental research and public health · 2021Article
- VCAM-1 Is Upregulated in Uranium Miners Compared to Other Miners.Life (Basel, Switzerland) · 2021Article
- Arsenic co-carcinogenesis: Inhibition of DNA repair and interaction with zinc finger proteins.Seminars in cancer biology · 2021Review
- Mine-site derived particulate matter exposure exacerbates neurological and pulmonary inflammatory outcomes in an autoimmune mouse model.Journal of toxicology and environmental health. Part A · 2021Article
- Uranium Exposure in American Indian Communities: Health, Policy, and the Way Forward.Environmental health perspectives · 2021Review
- Metal(loid)s inInternational journal of environmental research and public health · 2019Article
- A Review of Metal Exposure Studies Conducted in the Rural Southwestern and Mountain West Region of the United States.Current epidemiology reports · 2019Article
- Perspectives on Biological Monitoring in Environmental Health Research: A Focus Group Study in a Native American Community.International journal of environmental research and public health · 2018Article
Corrections and comments
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Authors and funding
14 authors at 2 institutions in 1 country.
Funding
Abstract
More than 500 abandoned uranium (U) mines within the Navajo Nation contribute U, arsenic (As) and other metals to groundwater, soil and potentially air through airborne transport. The adverse cardiovascular health effects attributed to cumulative exposure to these metals remains uncertain. The aim of this study was to examine whether environmental exposure to these metals may promote or exacerbate the oxidation of low-density lipoprotein (LDL) cholesterol in this Native American population. The correlation of cardiovascular biomarkers (oxidized LDL (oxLDL) and C-reactive protein (CRP)) from a Navajo cohort (n = 252) with mean annual As and U intakes from water and urine metals was estimated using linear regression. Proof-of-concept assays were performed to investigate whether As and U directly oxidize human LDL. Mean annual As intake from water was positively and significantly associated with oxLDL, but not CRP in this study population, while U intake estimates were negatively associated with oxLDL. In an acellular system, As, but not U, directly oxidized the apolipoprotein B-100 component of purified human LDL. Neither metal promoted lipid peroxidation of the LDL particle. Both the population and lab results are consistent with the hypothesis that As promotes oxidation of LDL, a crucial step in vascular inflammation and chronic vascular disease. Conversely, for outcomes related to U, negative associations were observed between U intake and oxLDL, and U only minimally altered human LDL in direct exposure experiments. Only urine U was correlated with CRP, whereas no other metals in water or urine were apparently reliable predictors of this inflammatory marker.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.