ArticleCurrent eye research2018
Retinal pH and Acid Regulation During Metabolic Acidosis.
Article in Current eye research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- Article
- pH in the vertebrate retina and its naturally occurring and pathological changes.Progress in retinal and eye research · 2025Review
- Diabetes-Induced Changes of the Rat ERG in Relation to Hyperglycemia and Acidosis.Current eye research · 2024Article
- Hyaluronic Acid: Its Versatile Use in Ocular Drug Delivery with a Specific Focus on Hyaluronic Acid-Based Polyelectrolyte Complexes.Pharmaceutics · 2022Review
- Determination of the pH dependence, substrate specificity, and turnovers of alternative substrates for human ornithine aminotransferase.The Journal of biological chemistry · 2022Article
- Synthesis and multifaceted pharmacological activity of novel quinazoline NHE-1 inhibitors.Scientific reports · 2021Article
- The therapeutic importance of acid-base balance.Biochemical pharmacology · 2021Review
- Abiotic and past climatic conditions drive protein abundance variation among natural populations of the caddisfly Crunoecia irrorata.Scientific reports · 2020Article
- Diabetes Alters pH Control in Rat Retina.Investigative ophthalmology & visual science · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
purposeChanges in retinal pH may contribute to a variety of eye diseases. To study the effect of acidosis alone, we induced systemic metabolic acidosis and hypothesized that the retina would respond with altered expression of genes involved in acid/base regulation.
methodsSystemic metabolic acidosis was induced in Long-Evans rats for up to 2 weeks by adding NH
resultsNH
conclusionsThe retina responds to systemic acidosis with increased expression of proton and bicarbonate exchangers, carbonic anhydrase, and ASICs. While responses to acidosis are usually associated with renal regulation, these studies suggest that the retina responds to changes in local pH presumably to control its acid/base environment in response to systemic acidosis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.