Evidence map›Paper›PMID 29641908›Full record

ReviewAnnual review of biomedical engineering2018

Arterial Venous Differentiation for Vascular Bioengineering.

Laura Niklason, Guohao Dai

Open access · greenAbstract readReview
In one paragraph

Review in Annual review of biomedical engineering, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
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  13. KnockdownBiomedicines · 2023
    Article
  14. Article
  15. Review
  16. Sourcing cells forFrontiers in medical technology · 2022
    Review
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Laura NiklasonVascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, Connecticut 06520, USA.
Guohao DaiDepartment of Bioengineering, Northeastern University, Boston, Massachusetts 02115, USA; email: g.dai@northeastern.edu.
Northeastern University · USYale University · US

Funding

Hyaluronan Coatings for Engineered VesselsR01HL127386 · NHLBI · YALE UNIVERSITY · PI NIKLASON, LAURA E · 2016 to 2019
$2.5M
Differentiating Embryonic Stem Cells Toward Arterial and Venous Endothelial Cells For Vascular RegenerationR01HL118245 · NHLBI · RENSSELAER POLYTECHNIC INSTITUTE · PI DAI, GUOHAO · 2013 to 2017
$1.9M
Control Arterial-Venous Differentiation Using 3-Dimensional Cell Printing TechnolR21HL102773 · NHLBI · RENSSELAER POLYTECHNIC INSTITUTE · PI DAI, GUOHAO · 2010 to 2011
$384k
NHLBI NIH HHS R01 HL118245NHLBI NIH HHS R01 HL127386NHLBI NIH HHS R21 HL102773
6 · The paper itself

Abstract

The development processes of arteries and veins are fundamentally different, leading to distinct differences in anatomy, structure, and function as well as molecular profiles. Understanding the complex interaction between genetic and epigenetic pathways, as well as extracellular and biomechanical signals that orchestrate arterial venous differentiation, is not only critical for the understanding of vascular diseases of arteries and veins but also valuable for vascular tissue engineering strategies. Recent research has suggested that certain transcriptional factors not only control arterial venous differentiation during development but also play a critical role in adult vessel function and disease processes. This review summarizes the signaling pathways and critical transcription factors that are important for arterial versus venous specification. We focus on those signals that have a direct relation to the structure and function of arteries and veins, and have implications for vascular disease processes and tissue engineering applications.

Indexed as

AnimalsArteriesBiomechanical PhenomenaCell DifferentiationEndothelial CellsEndothelium, VascularEpigenesis, GeneticHumansHypoxiaMicePluripotent Stem CellsSignal TransductionStem CellsTissue EngineeringTranscription FactorsVeinsTranscription Factorsarterial venous endothelial cellsstem cell differentiationvascular bioengineeringvascular development

Identifiers

PMID29641908
PMCPMC9235071
OpenAlexW2796499320

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.