ArticleMolecules (Basel, Switzerland)2018
Epigallocatechin Gallate-Modified Gelatin Sponges Treated by Vacuum Heating as a Novel Scaffold for Bone Tissue Engineering.
Article in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
- Rat Calvarial Defect Models in Bone Regeneration Research: A Narrative Review of Critical Size and Micro-Computed Tomography Outcome Reporting.Animals : an open access journal from MDPI · 2026Review
- Controlled EGCG Release from Zeolite-Coated Ti6Al4V: Effects of Divalent Ions on Release and Cytotoxicity.ACS biomaterials science & engineering · 2026Article
- Epigallocatechin gallate in dentistry: Therapeutic applications, biomaterial integration, and translational challenges.Journal of dental sciences · 2026Review
- Physicochemical and Antioxidant Alterations of Modified and Free Epigallocatechin Gallate Under Thermal Treatment in Air and Vacuum.Journal of functional biomaterials · 2025Article
- Review
- Synthetic Calcium-Phosphate Materials for Bone Grafting.Polymers · 2023Review
- Are Natural Compounds a Promising Alternative to Synthetic Cross-Linking Agents in the Preparation of Hydrogels?Pharmaceutics · 2023Review
- Review
- A photo-triggering double cross-linked adhesive, antibacterial, and biocompatible hydrogel for wound healing.iScience · 2022Article
- Functionalities of Gelatin Modified with 2-Octenyl Succinic Anhydride and Gallic Acid.Foods (Basel, Switzerland) · 2022Article
- Article
- Gas Permeability of Mold during Freezing Process Alters the Pore Distribution of Gelatin Sponge and Its Bone-Forming Ability.Materials (Basel, Switzerland) · 2020Article
- Repositioning Natural Antioxidants for Therapeutic Applications in Tissue Engineering.Bioengineering (Basel, Switzerland) · 2020Review
- Augmentation of Bone Regeneration by Depletion of Stress-Induced Senescent Cells Using Catechin and Senolytics.International journal of molecular sciences · 2020Article
- Releasing Behavior of Lipopolysaccharide from Gelatin Modulates Inflammation, Cellular Senescence, and Bone Formation in Critical-Sized Bone Defects in Rat Calvaria.Materials (Basel, Switzerland) · 2019Article
- Integration of Epigallocatechin Gallate in Gelatin Sponges Attenuates Matrix Metalloproteinase-Dependent Degradation and Increases Bone Formation.International journal of molecular sciences · 2019Article
- Catechin in Human Health and Disease.Molecules (Basel, Switzerland) · 2019Article
- Single Local Injection of Epigallocatechin Gallate-Modified Gelatin Attenuates Bone Resorption and Orthodontic Tooth Movement in Mice.Polymers · 2018Article
- Osteogenesis of Multipotent Progenitor Cells using the Epigallocatechin Gallate-Modified Gelatin Sponge Scaffold in the Rat Congenital Cleft-Jaw Model.International journal of molecular sciences · 2018Article
- Epigallocatechin Gallate-Modified Gelatins with Different Compositions Alter the Quality of Regenerated Bones.International journal of molecular sciences · 2018Article
Corrections and comments
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Authors and funding
14 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chemical modification of gelatin using epigallocatechin gallate (EGCG) promotes bone formation in vivo. However, further improvements are required to increase the mechanical strength and bone-forming ability of fabricated EGCG-modified gelatin sponges (EGCG-GS) for practical applications in regenerative therapy. In the present study, we investigated whether vacuum heating-induced dehydrothermal cross-linking of EGCG-GS enhances bone formation in critical-sized rat calvarial defects. The bone-forming ability of vacuum-heated EGCG-GS (vhEGCG-GS) and other sponges was evaluated by micro-computed tomography and histological staining. The degradation of sponges was assessed using protein assays, and cell morphology and proliferation were verified by scanning electron microscopy and immunostaining using osteoblastic UMR106 cells in vitro. Four weeks after the implantation of sponges, greater bone formation was detected for vhEGCG-GS than for EGCG-GS or vacuum-heated gelatin sponges (dehydrothermal cross-linked sponges without EGCG). In vitro experiments revealed that the relatively low degradability of vhEGCG-GS supports cell attachment, proliferation, and cell-cell communication on the matrix. These findings suggest that vacuum heating enhanced the bone forming ability of EGCG-GS, possibly via the dehydrothermal cross-linking of EGCG-GS, which provides a scaffold for cells, and by maintaining the pharmacological effect of EGCG.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.