ArticleThe British journal of radiology2018
The impact of contrast-enhanced spectral mammogram (CESM) and three-dimensional breast ultrasound (3DUS) on the characterization of the disease extend in cancer patients.
Article in The British journal of radiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 11 citations in OpenAlex.
- Effectiveness of Contrast-Enhanced Spectral Mammography Following Contrast-Enhanced Computed Tomography in Breast Cancer Diagnosis.Diagnostics (Basel, Switzerland) · 2026Article
- Multimodal feature fusion model for breast mass malignant risk stratification.Frontiers in oncology · 2026Article
- Advancing clinical staging in invasive breast carcinoma: the role of contrast-enhanced mammography.Polish journal of radiology · 2025Article
- Comparison between second-look ultrasound and second-look digital breast tomosynthesis in the detection of additional lesions with presurgical CESM.The British journal of radiology · 2022Article
- Diagnostic value of the enhancement intensity and enhancement pattern of CESM to benign and malignant breast lesions.Medicine · 2020Article
- A review on methods for diagnosis of breast cancer cells and tissues.Cell proliferation · 2020Review
- Technique, protocols and adverse reactions for contrast-enhanced spectral mammography (CESM): a systematic review.Insights into imaging · 2019Review
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Authors and funding
6 authors at 1 institution in 1 country.
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Abstract
objectiveThe main importance of imaging breast cancer is to guide conservative surgeries. In this study, we evaluated the role of contrast-enhanced spectral mammogram (CESM) in correlation with three-dimensional (3D) breast ultrasound in characterizing the extension of the intramammary cancer in view of the: (i) the size of the main tumor, (ii) the multiplicity of the breast cancer, and (iii) the peri-tumoral stromal involvement (i.e. free or intraductal extension of the cancer).
methodsThe study is a prospective analysis that included 300 breast masses proved to be malignant. The masses were evaluated for their size, multiplicity and surrounding stromal involvement. Contrast-based mammography performed with low (22-33 kVp) and high (44-49 kVp) energy exposures that were taken after i.v. injection of contrast agent and followed by bilateral 3D breast ultrasound. Operative data were the gold standard reference.
resultsThere was no significant difference between the sizes of the included cancers as measured by CESM and 3D ultrasound and that measured at the pathological analysis. CESM showed higher accuracy (32.7%, n = 98) than 3D ultrasound (24.7%, n = 74) in the size agreement within 5% range. CESM was the most accurate modality (94%, n = 282) in detecting tumor multiplicity, followed by traditional sonomammogram (88%, n = 264), then 3D breast ultrasound (84%, n = 252). Intraductal extension of the breast cancer was best evaluated by the 3D ultrasound with an accuracy value of 98% (n = 294) compared to only 60% (n = 180) by CESM.
conclusionCESM is a recommended investigation in breast cancer to increase the accuracy of size measurement and the detection of multiple tumors. The addition of 3D ultrasound can enhance the detection of intraductal extension. Advances in knowledge: Choice of conservative breast surgery vs mastectomy is still a debate. We used an advanced, contrast-based, application of the mammogram: CESM and a non-invasive 3D breast ultrasound in the assessment of the local extension of the breast cancer regarding size, perifocal stromal infiltration and multiplicity to guide the selection of proper management in proved cases of breast cancer.
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