ArticlePediatric research2018
Vascular endothelial growth factor accelerates compensatory lung growth by increasing the alveolar units.
Article in Pediatric research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- Downregulation of pigment epithelium-derived factor increases compensatory lung growth in mice after extended pneumonectomy.Pediatric research · 2026Article
- Intestinal failure-associated liver disease model: a reduced phytosterol intravenous lipid emulsion prevents liver injury.Pediatric research · 2025Article
- Molecular Hydrogen in the Treatment of Respiratory Diseases.International journal of molecular sciences · 2025Review
- Blood flow-induced angiocrine signals promote organ growth and regeneration.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- PLZF promotes compensatory lung growth by increasing HPMEC proliferation and angiogenesis.PloS one · 2025Article
- Innovative Use of Nanomaterials in Treating Retinopathy of Prematurity.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Direct thrombin inhibitors fail to reverse the negative effects of heparin on lung growth and function after murine left pneumonectomy.American journal of physiology. Lung cellular and molecular physiology · 2024Article
- A pneumonectomy model to study flow-induced pulmonary hypertension and compensatory lung growth.Cell reports methods · 2023Article
- Effects of systemic anticoagulation in a murine model of compensatory lung growth.Pediatric research · 2023Article
- Direct thrombin inhibitors as alternatives to heparin to preserve lung growth and function in a murine model of compensatory lung growth.Scientific reports · 2022Article
- Lipopolysaccharide-induced murine lung injury results in long-term pulmonary changes and downregulation of angiogenic pathways.Scientific reports · 2022Article
- Targeting the lung endothelial niche to promote angiogenesis and regeneration: A review of applications.Frontiers in molecular biosciences · 2022Review
- Effects of uteroplacental insufficiency on growth-restricted rats with altered lung development: A metabolomic analysis.Frontiers in pediatrics · 2022Article
- Alveologenesis: What Governs Secondary Septa Formation.International journal of molecular sciences · 2021Review
- Investigation of the mechanisms of VEGF-mediated compensatory lung growth: the role of the VEGF heparin-binding domain.Scientific reports · 2021Article
- A paradoxical method to enhance compensatory lung growth: Utilizing a VEGF inhibitor.PloS one · 2018Article
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
BackgroundDeficiency of vascular endothelial growth factor (VEGF) is associated with hypoplastic lung diseases, such as congenital diaphragmatic hernia. Provision of VEGF has been demonstrated to be beneficial in hyperoxia-induced bronchopulmonary dysplasia, and hence could induce lung growth and improve the outcome in hypoplastic lung diseases. We aimed to determine the effects of exogenous VEGF in a rodent model of compensatory lung growth after left pneumonectomy.MethodsEight-to-ten-week-old C57Bl6 male mice underwent left pneumonectomy, followed by daily intra-peritoneal injections of saline or VEGF (0.5 mg/kg). Lung volume measurement, pulmonary function tests, and morphometric analyses were performed on post-operative day (POD) 4 and 10. The pulmonary expression of angiogenic factors was analyzed by quantitative polymerase chain reaction and western blot.ResultsLung volume on POD 4 was higher in the VEGF-treated mice (P=0.03). On morphometric analyses, VEGF increased the parenchymal volume (P=0.001), alveolar volume (P=0.0003), and alveolar number (P<0.0001) on POD 4. The VEGF group displayed higher levels of phosphorylated-VEGFR2/VEGFR2 (P=0.03) and epidermal growth factor (EGF) messenger RNA (P=0.01).ConclusionVEGF accelerated the compensatory lung growth in mice, by increasing the alveolar units. These changes may be mediated by VEGFR2 and EGF-dependent mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.