Evidence map›Paper›PMID 29638128›Full record

ArticleThe Journal of organic chemistry2018

Convergent Synthesis of Sialyl Lewis

Mohammed Y R Sardar, Appi Reddy Mandhapati, Simon Park, Walter J Wever, Richard D Cummings, Elliot L Chaikof

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of organic chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Mohammed Y R SardarDepartment of Surgery, Center for Drug Discovery and Translational Research , Beth Israel Deaconess Medical Center, Harvard Medical School , 110 Francis Street, Suite 9F , Boston , Massachusetts 02215 , United States.
Appi Reddy MandhapatiDepartment of Surgery, Center for Drug Discovery and Translational Research , Beth Israel Deaconess Medical Center, Harvard Medical School , 110 Francis Street, Suite 9F , Boston , Massachusetts 02215 , United States.
Simon ParkDepartment of Surgery, Center for Drug Discovery and Translational Research , Beth Israel Deaconess Medical Center, Harvard Medical School , 110 Francis Street, Suite 9F , Boston , Massachusetts 02215 , United States.
Walter J WeverDepartment of Surgery, Center for Drug Discovery and Translational Research , Beth Israel Deaconess Medical Center, Harvard Medical School , 110 Francis Street, Suite 9F , Boston , Massachusetts 02215 , United States.ORCID 0000-0002-5754-0652
Richard D CummingsDepartment of Surgery, Center for Drug Discovery and Translational Research , Beth Israel Deaconess Medical Center, Harvard Medical School , 110 Francis Street, Suite 9F , Boston , Massachusetts 02215 , United States.
Elliot L ChaikofDepartment of Surgery, Center for Drug Discovery and Translational Research , Beth Israel Deaconess Medical Center, Harvard Medical School , 110 Francis Street, Suite 9F , Boston , Massachusetts 02215 , United States.ORCID 0000-0001-6184-4571
Beth Israel Deaconess Medical Center · US

Funding

Overall Priority Score P41GM103694 · NIGMS · EMORY UNIVERSITY · PI CUMMINGS, RICHARD D · 2013 to 2018
$6.9M
Facile Synthesis of Glycosulfopeptides and Related BioconjugatesU01GM116196 · NIGMS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI CHAIKOF, ELLIOT, CUMMINGS, RICHARD D · 2015 to 2018
$2.6M
A PSGL-1 Glycopeptide Mimetic for Treatment of Metabolic SyndromeR01DK107405 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI CHAIKOF, ELLIOT, KAHN, BARBARA B. · 2016 to 2019
$2.5M
A PSGL-1 Glycopeptide Mimetic for Treatment of Venous ThromboembolismR01HL128237 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI CHAIKOF, ELLIOT · 2015 to 2018
$1.7M
NHLBI NIH HHS R01 HL128237NIDDK NIH HHS R01 DK107405NIGMS NIH HHS P41 GM103694NIGMS NIH HHS U01 GM116196
6 · The paper itself

Abstract

Selectins are a class of cell adhesion molecules that play a critical role during the initial steps of inflammation. The N-terminal domain of P-selectin glycoprotein ligand-1 (PSGL-1) binds to all selectins, but with the highest affinity to P-selectin. Recent evidence suggests that the blockade of P-selectin/PSGL-1 interactions provides a viable therapeutic option for the treatment of many inflammatory diseases. Herein, we report the total synthesis of threonine bearing sialyl Lewis

Indexed as

Chemistry Techniques, SyntheticOligosaccharidesSialyl Lewis X AntigenThreonineOligosaccharidesSialyl Lewis X AntigenThreonine

Identifiers

PMID29638128
PMCPMC7648531
OpenAlexW2801162528

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.