Evidence map›Paper›PMID 29638114›Full record

ArticleACS synthetic biology2018

A Transcription Factor-Based Biosensor for Detection of Itaconic Acid.

Erik K R Hanko, Nigel P Minton, Naglis Malys

Open access · hybridAbstract read
In one paragraph

Article in ACS synthetic biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 70 citations in OpenAlex.

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  12. Biosensor development for single-cell detection of glucuronate.Journal of industrial microbiology & biotechnology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Erik K R HankoBBSRC/EPSRC Synthetic Biology Research Centre (SBRC), School of Life Sciences, Centre for Biomolecular Sciences , The University of Nottingham , Nottingham , NG7 2RD , United Kingdom.
Nigel P MintonBBSRC/EPSRC Synthetic Biology Research Centre (SBRC), School of Life Sciences, Centre for Biomolecular Sciences , The University of Nottingham , Nottingham , NG7 2RD , United Kingdom.
Naglis MalysBBSRC/EPSRC Synthetic Biology Research Centre (SBRC), School of Life Sciences, Centre for Biomolecular Sciences , The University of Nottingham , Nottingham , NG7 2RD , United Kingdom.ORCID 0000-0002-5010-310X
Engineering and Physical Sciences Research Council · GB

Funding

Biotechnology and Biological Sciences Research Council BB/L013940/1
6 · The paper itself

Abstract

Itaconic acid is an important platform chemical that can easily be incorporated into polymers and has the potential to replace petrochemical-based acrylic or methacrylic acid. A number of microorganisms have been developed for the biosynthesis of itaconate including Aspergillus terreus, Escherichia coli, and Saccharomyces cerevisiae. However, the number of strains and conditions that can be tested for increased itaconate titers are currently limited because of the lack of high-throughput screening methods. Here we identified itaconate-inducible promoters and their corresponding LysR-type transcriptional regulators from Yersinia pseudotuberculosis and Pseudomonas aeruginosa. We show that the YpItcR/P

Indexed as

Bacterial ProteinsBiosensing TechniquesCupriavidus necatorEscherichia coliFluorescenceFumaratesGene Expression RegulationLuminescent ProteinsMaleatesPromoter Regions, GeneticPseudomonas aeruginosaRed Fluorescent ProteinSuccinatesTranscription FactorsYersinia pseudotuberculosisBacterial Proteinscitraconic acidFumaratesitaconic acidLuminescent ProteinsLysR protein, BacteriaMaleatesRed Fluorescent ProteinSuccinatesTranscription Factorsfluorescence-based biosensorinducible gene expressionitaconic acidmacrophage infectionPseudomonas aeruginosaYersinia pseudotuberculosis

Identifiers

PMID29638114
PMCPMC6345495
OpenAlexW2797780355

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.