Evidence map›Paper›PMID 29638019›Full record

ArticleAdvanced materials (Deerfield Beach, Fla.)2018

A Hepatocyte-Mimicking Antidote for Alcohol Intoxication.

Duo Xu, Hui Han, Yuxin He, Harrison Lee, Di Wu, Fang Liu, Xiangsheng Liu, Yang Liu, Yunfeng Lu, Cheng Ji

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 32 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. A Multi-Enzyme Nanocascade to Target Disease-Relevant Metabolites.Small (Weinheim an der Bergstrasse, Germany) · 2025
    Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Duo XuDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, CA, 90095, USA.
Hui HanDepartment of Medicine, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, 90033, USA.
Yuxin HeDepartment of Medicine, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, 90033, USA.
Harrison LeeDepartment of Medicine, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, 90033, USA.
Di WuDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, CA, 90095, USA.
Fang LiuDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, CA, 90095, USA.
Xiangsheng LiuCalifornia NanoSystem Institute, Los Angeles, CA, 90095, USA.
Yang LiuState Key Laboratory of Medicinal Chemical Biology, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin, 300071, China.
Yunfeng LuDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, CA, 90095, USA.
Cheng JiDepartment of Medicine, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, 90033, USA.
University of California, Los Angeles · USUniversity of Southern California · USCalifornia NanoSystems Institute · USState Key Laboratory of Medicinal Chemical Biology

Funding

Primary role of Golgi stress in anti-HIV drug and alcohol abuse-induced hepatotoxicityR01DA042632 · NIDA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JI, CHENG · 2017 to 2021
$2.1M
Nanocapsules that decompose alcohol as antidotes for alcohol intoxication.R21AA023952 · NIAAA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JI, CHENG · 2015 to 2016
$417k
NIAAA NIH HHS R21 AA023952NIDA NIH HHS R01 DA042632
6 · The paper itself

Abstract

Alcohol intoxication causes serious diseases, whereas current treatments are mostly supportive and unable to remove alcohol efficiently. Upon alcohol consumption, alcohol is sequentially oxidized to acetaldehyde and acetate by the endogenous alcohol dehydrogenase and aldehyde dehydrogenase, respectively. Inspired by the metabolism of alcohol, a hepatocyte-mimicking antidote for alcohol intoxication through the codelivery of the nanocapsules of alcohol oxidase (AOx), catalase (CAT), and aldehyde dehydrogenase (ALDH) to the liver, where AOx and CAT catalyze the oxidation of alcohol to acetaldehyde, while ALDH catalyzes the oxidation of acetaldehyde to acetate. Administered to alcohol-intoxicated mice, the antidote rapidly accumulates in the liver and enables a significant reduction of the blood alcohol concentration. Moreover, blood acetaldehyde concentration is maintained at an extremely low level, significantly contributing to liver protection. Such an antidote, which can eliminate alcohol and acetaldehyde simultaneously, holds great promise for the treatment of alcohol intoxication and poisoning and can provide therapeutic benefits.

Indexed as

alcohol detoxificationbiomimetic antidotesenzyme nanocapsulesnanomedicine

Identifiers

PMID29638019
PMCPMC6386471
OpenAlexW2797309888

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.