ArticleDepression and anxiety2018
Cognitive performance in antidepressant-free recurrent major depressive disorder.
Article in Depression and anxiety, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Depression and episodic memory across the adult lifespan: A meta-analytic review.Psychological bulletin · 2021Pooled it
- Preliminary Evidence That Cortical Amyloid Burden Predicts Poor Response to Antidepressant Medication Treatment in Cognitively Intact Individuals With Late-Life Depression.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2021Trial
- Unpacking Post-Traumatic Stress Disorder and Mental Health in Internally Displaced Persons: A Mediation-Moderation Model of Psychological Capital and Perceived Social Support.International journal of environmental research and public health · 2025Article
- Cognitive, Disability, and Treatment Outcome Implications of Symptom-Based Phenotyping in Late-Life Depression.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2023Article
- Delirium, depression, and long-term cognition.International psychogeriatrics · 2023Article
- Factors associated with objective and subjective cognitive impairment in Chinese patients with acute major depressive disorder.BMC psychiatry · 2023Article
- Deficits in specific executive functions manifest by severity in major depressive disorder: a comparison of antidepressant naïve inpatient, outpatient, subclinical, and healthy control groups.Frontiers in psychiatry · 2023Article
- The pattern glare and visual memory are disrupted in patients with major depressive disorder.BMC psychiatry · 2022Article
- Association of brain white matter microstructure with cognitive performance in major depressive disorder and healthy controls: a diffusion-tensor imaging study.Molecular psychiatry · 2022Article
- Cognitive Impairment and Neurocognitive Profiles in Major Depression-A Clinical Perspective.Frontiers in psychiatry · 2022Review
- Cognitive Control, Cognitive Biases and Emotion Regulation in Depression: A New Proposal for an Integrative Interplay Model.Frontiers in psychology · 2021Review
- Accelerated brain aging predicts impaired cognitive performance and greater disability in geriatric but not midlife adult depression.Translational psychiatry · 2020Article
- A bayesian approach to examining default mode network functional connectivity and cognitive performance in major depressive disorder.Psychiatry research. Neuroimaging · 2020Article
- Brain network functional connectivity and cognitive performance in major depressive disorder.Journal of psychiatric research · 2019Article
- Effects of Opioid Dependence on Visuospatial Memory and Its Associations With Depression and Anxiety.Frontiers in psychiatry · 2019Article
- Opioid modulation of cognitive impairment in depression.Progress in brain research · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundCognitive complaints are common in depression, and cognition may be an important treatment target as cognitive problems often remain during remission and may contribute to recurrence risk. Previous studies of cognitive performance in depression have mainly examined late-life depression, with a focus on older adults, or assessed performance in specific cognitive tasks rather than cognitive domains.
methodsThis study examined cognitive performance across multiple cognitive domains in antidepressant-free depressed adults with early onset recurrent depression compared to never-depressed controls. Domain scores were calculated for episodic memory, executive function, processing speed, and working memory, and the effect of depression diagnosis, depression severity, and depression duration on each domain score was examined, including interactions with age, sex, and education.
resultsCurrently depressed adults (n = 91) exhibited poorer performance in the processing speed domain compared with never-depressed adults (n = 105). Additionally, there was an interactive effect of depression duration and age on processing speed and executive function domain performance, such that performance was worse with older age and longer duration of depression. There were no effects of depression severity on performance across the cognitive domains.
conclusionsThese findings support that processing speed deficits appear in young adults with early onset depression that may not be related to current mood. Additionally, the effects of cumulative depressive episodes may interact with aging such that cognitive performance deficits worsen with recurrence over the lifespan.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.