ArticleProtein science : a publication of the Protein Society2018
Weak IgG self- and hetero-association characterized by fluorescence analytical ultracentrifugation.
Article in Protein science : a publication of the Protein Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Analytical strategies for identification and quantitation of heterodimers in co-formulated monoclonal antibody cocktails by native SEC-MS.Scientific reports · 2025Article
- A scaling relationship between thermodynamic and hydrodynamic interactions in protein solutions.Biophysical journal · 2024Article
- Hydrodynamic and thermodynamic analysis of PEGylated human serum albumin.Biophysical journal · 2024Article
- The origins of nonideality exhibited by monoclonal antibodies and Fab fragments in human serum.Protein science : a publication of the Protein Society · 2023Article
- Simulation of Gilbert theory for self-association in sedimentation velocity experiments: a guide to evaluate best fitting models.European biophysics journal : EBJ · 2023Article
- Revisiting macromolecular hydration with HullRadSAS.European biophysics journal : EBJ · 2023Article
- Comparative Thermodynamics of the Reversible Self-Association of Therapeutic mAbs Reveal Opposing Roles for Linked Proton- and Ion-Binding Events.Pharmaceutical research · 2023Article
- LXR inhibitor SR9243-loaded immunoliposomes modulate lipid metabolism and stemness in colorectal cancer cells.Medical oncology (Northwood, London, England) · 2023Article
- Erythrocyte Membrane Biophysical Changes Mediated by Pooled Immunoglobulin G and Hematin: Electrokinetic and Lipid Peroxidation Studies.Membranes · 2023Article
- A Designer Nanoparticle Platform for Controlled Intracellular Delivery of Bioactive Macromolecules: Inhibition of Ubiquitin-Specific Protease 7 in Breast Cancer Cells.ACS chemical biology · 2022Article
- Use of Debye-Hückel-Henry charge measurements in early antibody development elucidates effects of non-specific association.Antibody therapeutics · 2022Article
- Global multi-method analysis of interaction parameters for reversibly self-associating macromolecules at high concentrations.Scientific reports · 2021Article
- Energetic Dissection of Mab-Specific Reversible Self-Association Reveals Unique Thermodynamic Signatures.Pharmaceutical research · 2021Article
- Analysis of nonideality: insights from high concentration simulations of sedimentation velocity data.European biophysics journal : EBJ · 2020Article
- Assessment of Antibody Self-Interaction by Bio-Layer-Interferometry as a Tool for Early Stage Formulation Development.Pharmaceutical research · 2020Article
- IgG Charge: Practical and Biological Implications.Antibodies (Basel, Switzerland) · 2019Article
- A Reappraisal of Sedimentation Nonideality Coefficients for the Analysis of Weak Interactions of Therapeutic Proteins.The AAPS journal · 2019Article
- AUC measurements of diffusion coefficients of monoclonal antibodies in the presence of human serum proteins.European biophysics journal : EBJ · 2018Article
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9 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Weak protein-protein interactions may be important to binding cooperativity. A panel of seven fluorescently labeled tracer monoclonal IgG antibodies, differing in variable (V) and constant (C) region sequences, were sedimented in increasing concentrations of unlabeled IgGs of identical, similar, and different backgrounds. Weak IgG::IgG attractive interactions were detected and characterized by global analysis of the hydrodynamic nonideality coefficient, k
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