Evidence map›Paper›PMID 29637625›Full record

ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2018

Genomewide Association Study Identifies Cxcl Family Members as Partial Mediators of LPS-Induced Periodontitis.

Sarah Hiyari, Elissa Green, Calvin Pan, Soma Lari, Mina Davar, Richard Davis, Paulo M Camargo, Sotirios Tetradis, Aldons J Lusis, Flavia Q Pirih

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 24 citations in OpenAlex.

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  8. Cxcl9l and Cxcr3.2 regulate recruitment of osteoclast progenitors to bone matrix in a medaka osteoporosis model.Proceedings of the National Academy of Sciences of the United States of America · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Sarah HiyariSection of Periodontics, University of California, Los Angeles, Los Angeles, CA, USA.
Elissa GreenSection of Periodontics, University of California, Los Angeles, Los Angeles, CA, USA.
Calvin PanDepartments of Medicine, Cardiology, and Human Genetics, University of California, Los Angeles, Los Angeles, CA, USA.
Soma LariSection of Periodontics, University of California, Los Angeles, Los Angeles, CA, USA.
Mina DavarSection of Periodontics, University of California, Los Angeles, Los Angeles, CA, USA.
Richard DavisDepartments of Medicine, Cardiology, and Human Genetics, University of California, Los Angeles, Los Angeles, CA, USA.
Paulo M CamargoSection of Periodontics, University of California, Los Angeles, Los Angeles, CA, USA.
Sotirios TetradisSection of Oral Radiology, University of California, Los Angeles, Los Angeles, CA, USA.
Aldons J LusisDepartments of Medicine, Cardiology, and Human Genetics, University of California, Los Angeles, Los Angeles, CA, USA.
Flavia Q PirihSection of Periodontics, University of California, Los Angeles, Los Angeles, CA, USA.
University of California, Los Angeles · US

Funding

Systems genomics of metabolic syndrome traitsP01HL028481 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LUSIS, ALDONS JAKE · 1985 to 2019
$50.2M
UCLA Dentist-Scientist and Oral Health-Researcher Training ProgramT90DE022734 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WONG, DAVID T · 2012 to 2017
$2.3M
Mouse Genome-Wide Association Studies in LPS-Induced Bone LossR21DE023901 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PIRIH, FLAVIA · 2014 to 2015
$407k
NHLBI NIH HHS P01 HL028481NIDCR NIH HHS R21 DE023901NIDCR NIH HHS T90 DE022734
6 · The paper itself

Abstract

Periodontitis (PD) is characterized by bacterial infection and inflammation of tooth-supporting structures and can lead to tooth loss. PD affects ∼47% of the US population over age 30 years and has a heritability of about 50%. Although the host immunoinflammatory response and genetic background play a role, little is known of the underlying genetic factors. We examined natural genetic variation in lipopolysaccharide (LPS)-induced PD across a panel of inbred mouse strains, the hybrid mouse diversity panel (HMDP). We observed a strain-dependent sixfold difference in LPS-induced bone loss across the HMDP with a heritability of 53%. We performed a genomewide association study (GWAS) using FAST-LMM, which corrects for population structure, and identified loci significantly associated with PD. We examined candidate genes at a locus on chromosome 5, which suggested a relationship between LPS-induced bone loss and, together with expression data, identified Cxcl family members as associated with PD. We observed an increase in Cxcl10 protein, as well as immune cells and pro-inflammatory cytokines in C57BL/6J (high bone loss strain) but not in A/J (low bone loss strain) after LPS injections. Genetic deletion of CXCR3 (Cxcl9 and10 receptor) demonstrated a ∼50% reduction in bone loss and reduced osteoclasts after LPS injections. Furthermore, WT mice treated with AMG-487 (a CXCR3 antagonist) showed a ∼45% reduction in bone loss and decreased osteoclasts after LPS injections. We conclude that CXCR3 is a strong candidate for modulating the host response in individuals susceptible to PD. © 2018 American Society for Bone and Mineral Research.

Indexed as

Genome-Wide Association StudyAcetamidesAlveolar Bone LossAnimalsBiomarkersChemokines, CXCFemaleGene Expression RegulationInflammation MediatorsLipopolysaccharidesMacrophagesMaleMice, Inbred C57BLMice, KnockoutOsteoclastsPeriodontitisAcetamidesBiomarkersChemokines, CXCCxcr3 protein, mouseInflammation MediatorsLipopolysaccharidesN-(1-(3-(4-ethoxyphenyl)-4-oxo-3,4-dihydropyrido(2,3-d)pyrimidin-2-yl)ethyl)-N-pyridin-3-ylmethyl-2-(4-trifluoromethoxyphenyl)acetamidePyrimidinonesReceptors, CXCR3ANIMAL MODELSDENTAL BIOLOGYDISEASES AND DISORDERS OF/RELATED TO BONEGENETIC ANIMAL MODELSPERIODONTAL DISEASEPERIODONTITISTHERAPEUTICS

Identifiers

PMID29637625
PMCPMC8434897
OpenAlexW2796843679

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.