ArticleArchives of insect biochemistry and physiology2018
Overexpression of antimicrobial peptides contributes to aging through cytotoxic effects in Drosophila tissues.
Article in Archives of insect biochemistry and physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed, 99 citations in OpenAlex.
- Fat body CLOCK restrains innate immunity and maintains survival under dietary stress inbioRxiv : the preprint server for biology · 2026Article
- Beyond Antimicrobial Defense: Insect Antimicrobial Peptides as Neuroimmune Effectors and Insect-Derived Peptide Resources.Insects · 2026Review
- Shielded by the dead: how killed bacteria shape the dynamics and evolution of innate immunity.bioRxiv : the preprint server for biology · 2026Article
- Sex-specific effects of cereal-based diets on longevity and healthspan in Drosophila melanogaster.Biogerontology · 2026Article
- Review
- AAGP integrates physicochemical and compositional features for machine learning-based prediction of anti-aging peptides.Scientific reports · 2025Article
- Article
- Article
- LRRK2 in Drosophila Melanogaster Model: Insights into Cellular Dysfunction and Neuroinflammation in Parkinson's Disease.International journal of molecular sciences · 2025Review
- Effects of Silibinin on Delaying Aging inAntioxidants (Basel, Switzerland) · 2025Article
- Chronic bacterial infections exert metabolic costs in Drosophila melanogaster.The Journal of experimental biology · 2025Article
- Emerging roles of antimicrobial peptides in innate immunity, neuronal function, and neurodegeneration.Trends in neurosciences · 2024Review
- The role of uncertainty and negative feedback loops in the evolution of induced immune defenses.G3 (Bethesda, Md.) · 2024Article
- Evaluation of Neuroinflammatory Contribution to Neurodegeneration in LRRK2Biomedicines · 2024Article
- Inhibition of S6K lowers age-related inflammation and increases lifespan through the endolysosomal system.Nature aging · 2024Article
- Mapping the functional form of the trade-off between infection resistance and reproductive fitness under dysregulated immune signaling.PLoS pathogens · 2024Article
- The evolution of constitutively active humoral immune defenses in Drosophila populations under high parasite pressure.PLoS pathogens · 2024Article
- Human breast milk isolated lactic acid bacteria: antimicrobial and immunomodulatory activity on theFrontiers in cellular and infection microbiology · 2024Article
- Unraveling lipid and inflammation interplay in cancer, aging and infection for novel theranostic approaches.Frontiers in immunology · 2024Review
- Mutations in abnormal spindle disrupt temporal transcription factor expression and trigger immune responses in the Drosophila brain.Genetics · 2023Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
The innate immune response tends to become hyperactive and proinflammatory in older organisms. We investigated connections between activity of the immune-related genes and aging using the Drosophila model. A hallmark of Drosophila immunity is the production of antimicrobial peptides (AMP), whose expression is triggered via activation of the Toll and Imd immune pathways and regulated by NF-ĸB-like transcription factors, Dif/Dorsal and Relish. It was previously shown that overexpression of the upstream component of the immune pathways shortens lifespan via activation of the Relish-dependent immune response. Here we show that direct overexpression of the Relish target AMP genes broadly at high levels or in the fat body induced apoptosis, elicited depolarization of the mitochondria and significantly shortened lifespan. Underexpression of Relish in the fat body beginning in the second half of lifespan prevented overactivation of AMPs and extended longevity. Unlike infection-induced responses, the age-related increase in AMPs does not require the upstream recognition/transduction module of the Imd pathway. It does however require downstream elements, including Relish and Ird5, a component of the downstream IKK complex. Together, these results established causal links between high-level production of antimicrobial peptides and longevity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.