Evidence map›Paper›PMID 29637518›Full record

ArticleNeurocritical care2018

Cerebrovascular Events After Continuous-Flow Left Ventricular Assist Devices.

Pouya Tahsili-Fahadan, David R Curfman, Albert A Davis, Noushin Yahyavi-Firouz-Abadi, Lucia Rivera-Lara, Michael E Nassif, Shane J LaRue, Gregory A Ewald, Allyson R Zazulia

Abstract read
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In one paragraph

Article in Neurocritical care, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Pouya Tahsili-FahadanDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
David R CurfmanDepartment of Neurology, Washington University School of Medicine, 660 S. Euclid Avenue, Campus, Box 8111, St. Louis, MO, 63110, USA.
Albert A DavisDepartment of Neurology, Washington University School of Medicine, 660 S. Euclid Avenue, Campus, Box 8111, St. Louis, MO, 63110, USA.
Noushin Yahyavi-Firouz-AbadiDepartment of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Lucia Rivera-LaraDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Michael E NassifDepartment of Medicine, Cardiovascular Division, Washington University School of Medicine, St. Louis, MO, USA.
Shane J LaRueDepartment of Medicine, Cardiovascular Division, Washington University School of Medicine, St. Louis, MO, USA.
Gregory A EwaldDepartment of Medicine, Cardiovascular Division, Washington University School of Medicine, St. Louis, MO, USA.
Allyson R ZazuliaDepartment of Neurology, Washington University School of Medicine, 660 S. Euclid Avenue, Campus, Box 8111, St. Louis, MO, 63110, USA. zazuliaa@wustl.edu.

Funding

SALsalate to Improve Exercise toleraNce and LVDD in T2dm-DHF (SALIENT-DHF trial)U10HL110309 · NHLBI · WASHINGTON UNIVERSITY · PI DAVILA-ROMAN, VICTOR G., MANN, DOUGLAS L · 2012 to 2018
$3.5M
NIH HHS HL097036NIH HHS U10 HL110309
6 · The paper itself

Abstract

backgroundCerebrovascular events (CVE) are among the most common and serious complications after implantation of continuous-flow left ventricular assist devices (CF-LVAD). We studied the incidence, subtypes, anatomical distribution, and pre- and post-implantation risk factors of CVEs as well as the effect of CVEs on outcomes after CF-LVAD implantation at our institution.

methodsRetrospective analysis of clinical and neuroimaging data of 372 patients with CF-LVAD between May 2005 and December 2013 using standard statistical methods.

resultsCVEs occurred in 71 patients (19%), consisting of 35 ischemic (49%), 26 hemorrhagic (37%), and 10 ischemic+hemorrhagic (14%) events. History of coronary artery disease and female gender was associated with higher odds of ischemic CVE (OR 2.84 and 2.5, respectively), and diabetes mellitus was associated with higher odds of hemorrhagic CVE (OR 3.12). While we found a higher rate of ischemic CVEs in patients not taking any antithrombotic medications, no difference was found between patients with ischemic and hemorrhagic CVEs. Occurrence of CVEs was associated with increased mortality (HR 1.62). Heart transplantation was associated with improved survival (HR 0.02). In patients without heart transplantation, occurrence of CVE was associated with decreased survival.

conclusionsLVADs are associated with high rates of CVE, increased mortality, and lower rates of heart transplantation. Further investigations to identify the optimal primary and secondary stroke prevention measures in post-LVAD patients are warranted.

Indexed as

Brain IschemiaHeart-Assist DevicesHeart FailureHeart TransplantationIntracranial HemorrhagesStrokeAgedFemaleHumansMaleMiddle AgedRisk FactorsCardiac transplantHeart failureLeft ventricular assist deviceStroke

Identifiers

PMID29637518

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.