ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2018
OCTA vessel density changes in the macular zone in glaucomatous eyes.
Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 88 citations in OpenAlex.
- OCT-angiography: Regional reduced macula microcirculation in ocular hypertensive and pre-perimetric glaucoma patients.PloS one · 2021Trial
- Optical coherence tomography angiography of the macular retina and choroid in glaucoma: a narrative review.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Review
- Smaller Optic Discs Show Higher Macular Flow Density: An Optical Coherence Tomography Angiography Study.Biomedicines · 2026Article
- Comparative analysis of optical coherence tomography angiography metrics in primary open-angle glaucoma and ocular hypertension.BMC ophthalmology · 2026Article
- A comparative evaluation of parafoveal and perifoveal macular vessel density loss in glaucoma using 3 × 3 mm OCTA scans.Scientific reports · 2026Article
- Comparison of Peripapillary and Submacular Choroidal Changes After Trabeculectomy and Phaco-Trabeculectomy in Open-Angle Glaucoma.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
- Longitudinal quantitative assessment of macular retinal and choroidal remodeling after trabeculectomy in chronic primary angle-closure glaucoma using ultra-widefield SS-OCTA.Scientific reports · 2025Observational
- ET-1, MMPs, ZAG, and APN Link Reduced Ocular Perfusion to Glaucoma.Biomolecules · 2025Article
- Correlating 10-2 Visual Field Loss with Structural and Angiographic Parameters in Advanced Glaucoma.Ophthalmology and therapy · 2025Article
- Macular vascular density changes in different stages of chronic primary angle-closure glaucoma.Frontiers in medicine · 2025Article
- Unveiling Novel Structural Biomarkers for the Diagnosis of Glaucoma.Biomedicines · 2024Review
- Glaucoma detection using non-perfused areas in OCTA.Scientific reports · 2024Article
- Applications of optical coherence tomography angiography in glaucoma: current status and future directions.Frontiers in medicine · 2024Review
- Orbital decompression improves visual function and macular blood perfusion status in patients with thyroid-related eye disease.Frontiers in medicine · 2024Article
- Relationships of Macular Functional Impairment With Structural and Vascular Changes According to Glaucoma Severity.Investigative ophthalmology & visual science · 2023Article
- Factors Associated with Vascular Changes at the Level of Retinal Ganglion Cell Axon versus Soma/Dendrite in Glaucoma Patients.Journal of clinical medicine · 2023Article
- Association of superficial macular vessel density with visual field progression in open-angle glaucoma with central visual field damage.Scientific reports · 2023Article
- Deep Learning in Optical Coherence Tomography Angiography: Current Progress, Challenges, and Future Directions.Diagnostics (Basel, Switzerland) · 2023Review
- Peripapillary and macular vascular densities in healthy, ocular hypertensive, and different stages of glaucomatous eyes.International journal of ophthalmology · 2023Article
- Current State of Knowledge in Ocular Blood Flow in Glaucoma: A Narrative Review.Clinical ophthalmology (Auckland, N.Z.) · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate whether macular optical coherence tomography angiography (OCTA) can detect altered vessel density (VD) in the superficial and deep vascular plexus in glaucomatous eyes and to compare the diagnostic utility of the individual VD parameters.
methodsThe macular VD of 135 eyes, comprising 85 eyes diagnosed with glaucoma and 50 healthy control eyes, was examined using two OCTA devices (AngioPlex-Zeiss Meditec, Inc., Dublin, CA, USA, and AngioVue-OptoVue, Inc., Fremont, CA, USA). All study participants had neither vascular pathology, diabetes, nor vasoactive medication. The macular VD was measured at two different levels of segmentation (superficial [SL] and deep [DL] retinal vascular plexus) with a 6 × 6-mm macula scan, and VD was correlated with various structural and functional measurements. In order to test the accuracy of differentiation between eyes with and without glaucoma, we calculated the receiver operating characteristic (ROC) curve and the area under the curve (AUC).
resultsMacular VD was significantly lower in both SL and DL in glaucomatous eyes than in healthy eyes (p = SL < 0.0001; DL = 0.009). There was no significant difference in VD between the SL and the DL (p = 6.60 · 10
conclusionOCTA detects glaucomatous damage by measuring the macular vessel density in the superficial and deep retinal vascular plexus. It can be an additional diagnostic tool to detect glaucoma independently of the optic nerve.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.