Evidence map›Paper›PMID 29637134›Full record

ArticleBMJ paediatrics open2017

Burden of severe neonatal jaundice: a systematic review and meta-analysis.

Tina M Slusher, Tara G Zamora, Duke Appiah, Judith U Stanke, Mark A Strand, Burton W Lee, Shane B Richardson, Elizabeth M Keating, Ashajoythi M Siddappa, Bolajoko O Olusanya

2 registry-linked trialsOpen access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ paediatrics open, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 105 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
105citing papers in PubMed, 6 pooled it
17.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03880591 completednot on this mapstarted 2019, after this paper: background citation

Baseline Assessment of Neonatal Hyperbilirubinaemia in a Cohort of New-borns in Kinshasa, Democratic Republic of Congo

TypeobservationalSponsorUniversity of OxfordRan2019 to 2020Enrolled306ConditionsNeonatal Hyperbilirubinemia
NCT06075108 narecruitingnot on this mapstarted 2024, after this paper: background citation

P-KIDs CARE: An Intervention to Address Health Systems Delays to Care for Injured Children in Tanzania

TypeinterventionalSponsorUniversity of UtahRan2024 to 2028Enrolled284ConditionsAccidental Injuries, Global Child Health, Pediatric Emergency Medicine, Public Health System ResearchArmsP-KIDs CARE
3 · Its place in the literature

Who cites it

105 citing papers in PubMed, 6 syntheses or guidelines pooled it, 227 citations in OpenAlex.

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45 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 2 countries.

Tina M SlusherDepartment of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA.
Tara G ZamoraDepartment of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA.
Duke AppiahTexas Tech University Health Science Center, Abilene, Texas, USA.
Judith U StankeBiomedical Library, University of Minnesota, Minneapolis, Minnesota, USA.
Mark A StrandDepartment of Pharmacy, North Dakota State University, Fargo, North Dakota, USA.
Burton W LeeDepartment of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Shane B RichardsonDepartment of Family Medicine, University of Arizona, Tucson, Arizona, USA.
Elizabeth M KeatingDepartment of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.
Ashajoythi M SiddappaDepartment of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA.
Bolajoko O OlusanyaCenter for Healthy Start Initiative, Lagos, Nigeria.ORCID 0000-0002-3826-0583
University of Minnesota · USBaylor College of Medicine · USCentre for Healthy Start Initiative · NGDakota State University · USTexas Tech University · USUniversity of Arizona · USUniversity of Pittsburgh · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextTo assess the global burden of late and/or poor management of severe neonatal jaundice (SNJ), a common problem worldwide, which may result in death or irreversible brain damage with disabilities in survivors. Population-based data establishing the global burden of SNJ has not been previously reported.

objectiveDetermine the burden of SNJ in all WHO regions, as defined by clinical jaundice associated with clinical outcomes including acute bilirubin encephalopathy/kernicterus and/or exchange transfusion (ET) and/or jaundice-related death. DATA SOURCES: PubMed, Scopus and other health databases were searched, without language restrictions, from 1990 to 2017 for studies reporting the incidence of SNJ. STUDY SELECTION/DATA EXTRACTION: Stratification was performed for WHO regions and results were pooled using random effects model and meta-regression.

resultsOf 416 articles including at least one marker of SNJ, only 21 reported estimates from population-based studies, with 76% (16/21) of them conducted in high-income countries. The African region has the highest incidence of SNJ per 10 000 live births at 667.8 (95% CI 603.4 to 738.5), followed by Southeast Asian, Eastern Mediterranean, Western Pacific, Americas and European regions at 251.3 (132.0 to 473.2), 165.7 (114.6 to 238.9), 9.4 (0.1 to 755.9), 4.4 (1.8 to 10.5) and 3.7 (1.7 to 8.0), respectively. The incidence of ET per 10 000 live births was significantly higher for Africa and Southeast Asian regions at 186.5 (153.2 to 226.8) and 107.1 (102.0 to 112.5) and lower in Eastern Mediterranean (17.8 (5.7 to 54.9)), Americas (0.38 (0.21 to 0.67)), European (0.35 (0.20 to 0.60)) and Western Pacific regions (0.19 (0.12 to 0.31). Only 2 studies provided estimates of clear jaundice-related deaths in infants with significant jaundice [UK (2.8%) and India (30.8%).

conclusionsLimited but compelling evidence demonstrates that SNJ is associated with a significant health burden especially in low-income and middle-income countries.

Indexed as

jaundiceneonatology

Identifiers

PMID29637134
PMCPMC5862199
OpenAlexW2769944765

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.