ArticlePLoS currents2018
A Nosocomial Outbreak of Clinical Sepsis in a Neonatal Care Unit (NCU) in Port-Au-Prince Haiti, July 2014 - September 2015.
Article in PLoS currents, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Contemporary Trends in Global Mortality of Sepsis Among Young Infants Less Than 90 Days: A Systematic Review and Meta-Analysis.Frontiers in pediatrics · 2022Pooled it
- Extended spectrum beta-lactamase Klebsiella pneumoniae (ESBL-KP) bloodstream infection outbreak in a Neonatal Intensive Care Unit (NICU) in Bangui, Central African Republic (CAR).Antimicrobial resistance and infection control · 2026Article
- Observational
- Article
- Prevalence of MDR bacteria in an acute trauma hospital in Port-au-Prince, Haiti: a retrospective analysis from 2012 to 2018.JAC-antimicrobial resistance · 2021Article
- Growth and neurodevelopment in low birth weight versus normal birth weight infants from birth to 24 months, born in an obstetric emergency hospital in Haiti, a prospective cohort study.BMC pediatrics · 2021Article
- MSF Paediatric Days: a step forward in operationalising 'Humanitarian Paediatrics'.BMJ paediatrics open · 2021Review
- Disposable low-cost cardboard incubator for thermoregulation of stable preterm infant - a randomized controlled non-inferiority trial.EClinicalMedicine · 2021Article
- Successful control of an extended-spectrum beta-lactamase-producing Klebsiella pneumoniae ST307 outbreak in a neonatal intensive care unit.BMC infectious diseases · 2020Article
- Genomic Epidemiology of an Outbreak ofInfection and drug resistance · 2020Article
- Antibiotic resistance in conflict settings: lessons learned in the Middle East.JAC-antimicrobial resistance · 2019Article
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3 authors.
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Abstract
introductionBetween July 2014 and September 2015, a neonatal care unit (NCU) in Port Au Prince, Haiti, experienced an outbreak of sepsis, most probably due to nosocomial transmission of Extended Beta Lactamase (ESBL) producing gram negative bacteria, included Klebsiella pneumoniae.
methodsWe describe the epidemiological and microbiological activities performed as part of the outbreak investigation and the control measures implemented throughout this period.
resultsDuring the study period 257 cases of sepsis were reported, of which 191 died. The case fatality decreased from 100% in July 2014 to 24% in September 2015 and could be attributed to an improvement in clinical management and strengthened infection prevention and control measures. Risk factors identified to be associated with having late onset sepsis (sepsis onset >48 hours after birth)(n=205/257, 79. included: all categories of birthweight lower than <2500g (p=<0.0001) and all categories of gestational age younger than 36 weeks (p=0.0002). Microbiological investigations confirmed that out of 32 isolates (N=55; 58%) that were positive for gram negative bacteria, 27 (89%) were due to K. pneumoniae and most of these were from single MLST type (ST37). DISCUSSION: This outbreak highlighted the importance of epidemiological and microbiological surveillance during an outbreak of sepsis in a NCU in a low resource setting, including regular point prevalence surveys.
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