Evidence map›Paper›PMID 29636977›Full record

ArticlePharmacology research & perspectives2018

Electrical dynamics of isolated cerebral and skeletal muscle endothelial tubes: Differential roles of G-protein-coupled receptors and K

Md A Hakim, John N Buchholz, Erik J Behringer

Abstract read
In one paragraph

Article in Pharmacology research & perspectives, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. The interaction between dysfunction of vasculature and tauopathy in Alzheimer's disease and related dementias.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review
  3. Endothelial KAmerican journal of physiology. Heart and circulatory physiology · 2023
    Article
  4. Article
  5. KMicrocirculation (New York, N.Y. : 1994) · 2023
    Article
  6. Article
  7. Methyl-Beta-Cyclodextrin Restores KJournal of Alzheimer's disease reports · 2021
    Article
  8. Aging Alters Cerebrovascular Endothelial GPCR and K+ Channel Function: Divergent Role of Biological Sex.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020
    Article
  9. Article
  10. Functional Interaction among KInternational journal of molecular sciences · 2019
    Review
  11. Article
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Md A HakimBasic Sciences Loma Linda University Loma Linda CA USA.ORCID 0000-0002-6183-7950
John N BuchholzBasic Sciences Loma Linda University Loma Linda CA USA.ORCID 0000-0002-8356-3831
Erik J BehringerBasic Sciences Loma Linda University Loma Linda CA USA.ORCID 0000-0001-6979-2796

Funding

Impact of aging on calcium and electrical signaling in microvascular endotheliumR00AG047198 · NIA · LOMA LINDA UNIVERSITY · PI BEHRINGER, ERIK J. · 2015 to 2017
$732k
Impact of aging on calcium and electrical signaling in microvascular endotheliumK99AG047198 · NIA · UNIVERSITY OF MISSOURI-COLUMBIA · PI BEHRINGER, ERIK J. · 2014 to 2015
$175k
NIA NIH HHS K99 AG047198NIA NIH HHS R00 AG047198
6 · The paper itself

Abstract

Electrical dynamics of freshly isolated cerebral endothelium have not been determined independently of perivascular nerves and smooth muscle. We tested the hypothesis that endothelium of cerebral and skeletal muscle arteries differentially utilizes purinergic and muscarinic signaling pathways to activate endothelium-derived hyperpolarization. Changes in membrane potential (

Indexed as

AnimalsArteriesCerebral CortexEndothelial CellsEndothelium, VascularFemaleIn Vitro TechniquesMaleMembrane PotentialsMice, Inbred C57BLMuscle, SkeletalMuscle, Smooth, VascularPotassium ChannelsReceptors, G-Protein-CoupledPotassium ChannelsReceptors, G-Protein-Coupledcalcium‐activated K+ channelsendothelium‐derived hyperpolarizationmuscarinicpurinergic

Identifiers

PMID29636977
PMCPMC5889193

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.