ArticleAmerican journal of translational research2018
Qihuang decoction promotes the recovery of intestinal immune barrier dysfunction after gastrectomy in rats.
Article in American journal of translational research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- Immune Enhancement of FermentedMolecules (Basel, Switzerland) · 2025Article
- Inhibiting Rac1 signaling alleviates DSS-induced colitis by improving inflammatory response and intestinal permeability.Gastroenterology report · 2025Article
- A Study of the Resistance of Hu Sheep Lambs toAnimals : an open access journal from MDPI · 2024Article
- Panax notoginseng saponins alleviate damage to the intestinal barrier and regulate levels of intestinal microbes in a rat model of chronic kidney disease.Renal failure · 2022Article
- Efficacy of Qihuang decoction on enteric nervous system in rats after gastrectomy.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2022Article
- Effect of Qihuang Decoction Combined with Enteral Nutrition on Postoperative Gastric Cancer of Nutrition and Immune Function.Evidence-based complementary and alternative medicine : eCAM · 2020Article
- Hyperbaric Oxygen Treatment Improves Intestinal Barrier Function After Spinal Cord Injury in Rats.Frontiers in neurology · 2020Article
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aims to observe the effect of Qihuang decoction on small intestinal mucosal barrier after gastrectomy in rats. MATERIALS AND
methodsA total of 80 Wistar rats were randomly divided into normal group, sham operation group, enteral nutrition group (EN) and Qihuang decoction group (EN+QH), there were 20 rats in each group. Both the EN group and the EN+QH group underwent gastrectomy. Instillation of enteral nutrition in the small intestine was performed after operation in the EN group. Instillation of enteral nutrition and Qihuang decoction in the small intestine was performed after operation in the EN+QH group. Only the abdominal incision and closing was performed in the sham operation group without drug and nutritional intervention. The expression levels of tight junction proteins in intestinal epithelial cells were determined by western blotting method. The sIgA content in different anatomic sites of intestinal mucosa was determined by double antibody-PEG radioimmunoassay technique. The number of IgA+B cells in different anatomic sites of intestinal mucosa was determined by immunohistochemical method.
resultsThe sIgA content in the sham operated group was significantly lower than that of normal group (
conclusionsQihuang decoction can promote the proliferation and differentiation of IgA+B lymphocytes and increase the sIgA content in intestinal mucosal immune barrier after gastrectomy in rats, it also can promote the expression of tight junction proteins to improve the permeability of intestinal mucosa and promote the recovery of intestinal immune barrier dysfunction in rats after gastrectomy by inhibiting the tight junction associated proteins' phosphorylation induced by Rho/ROCK signaling pathway.
Indexed as
Identifiers
29636872PMC5883123W2972364741What OpenQuestion holds
Registered trials
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