Evidence map›Paper›PMID 29636844›Full record

ArticleOxidative medicine and cellular longevity2018

Role of miR-200c in Myogenic Differentiation Impairment via p66Shc: Implication in Skeletal Muscle Regeneration of Dystrophic

Marco D'Agostino, Alessio Torcinaro, Luca Madaro, Lorenza Marchetti, Sara Sileno, Sara Beji, Chiara Salis, Daisy Proietti, Giulia Imeneo, Maurizio C Capogrossi and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Zeb1 and Tle3 are trans-factors that differentially regulate the expression of myosin heavy chain-embryonic and skeletal muscle differentiation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023
    Article
  6. Article
  7. Article
  8. Review
  9. Genistein Promotes Skeletal Muscle Regeneration by Regulating miR-221/222.International journal of molecular sciences · 2022
    Article
  10. Article
  11. Article
  12. An Emerging Role for Epigenetics in Cerebral Palsy.Journal of personalized medicine · 2021
    Review
  13. Review
  14. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Marco D'AgostinoDepartment of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy.
Alessio TorcinaroDepartment of Biology and Biotechnology "Charles Darwin", Sapienza University of Rome, Roma, Italy.
Luca MadaroFondazione Santa Lucia IRCCS, 00143 Rome, Italy.ORCID 0000-0003-0839-5724
Lorenza MarchettiVascular Pathology Laboratory, Instituto Dermopatico dell'Immacolata-IRCCS, FLMM, Via dei Monti di Creta 104, 00167 Rome, Italy.ORCID 0000-0001-5745-8547
Sara SilenoVascular Pathology Laboratory, Instituto Dermopatico dell'Immacolata-IRCCS, FLMM, Via dei Monti di Creta 104, 00167 Rome, Italy.ORCID 0000-0002-2036-2071
Sara BejiVascular Pathology Laboratory, Instituto Dermopatico dell'Immacolata-IRCCS, FLMM, Via dei Monti di Creta 104, 00167 Rome, Italy.
Chiara SalisVascular Pathology Laboratory, Instituto Dermopatico dell'Immacolata-IRCCS, FLMM, Via dei Monti di Creta 104, 00167 Rome, Italy.
Daisy ProiettiFondazione Santa Lucia IRCCS, 00143 Rome, Italy.ORCID 0000-0001-6292-8849
Giulia ImeneoInstitute of Cell Biology and Neurobiology (IBCN), Italian National Research Council (CNR), 00143 Rome, Italy.ORCID 0000-0001-8400-9448
Maurizio C CapogrossiVascular Pathology Laboratory, Instituto Dermopatico dell'Immacolata-IRCCS, FLMM, Via dei Monti di Creta 104, 00167 Rome, Italy.
Francesca De SantaInstitute of Cell Biology and Neurobiology (IBCN), Italian National Research Council (CNR), 00143 Rome, Italy.
Alessandra MagentaVascular Pathology Laboratory, Instituto Dermopatico dell'Immacolata-IRCCS, FLMM, Via dei Monti di Creta 104, 00167 Rome, Italy.ORCID 0000-0002-9054-337X
Istituto Dermopatico dell'Immacolata · ITNational Academies of Sciences, Engineering, and Medicine · USFondazione Santa Lucia · ITOchsner Medical Center · USSapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Duchenne muscular dystrophy (DMD) is a genetic disease associated with mutations of Dystrophin gene that regulate myofiber integrity and muscle degeneration, characterized by oxidative stress increase. We previously published that reactive oxygen species (ROS) induce miR-200c that is responsible for apoptosis and senescence. Moreover, we demonstrated that miR-200c increases ROS production and phosphorylates p66Shc in Ser-36. p66Shc plays an important role in muscle differentiation; we previously showed that p66Shc

Indexed as

RegenerationAnimalsCell DifferentiationCell LineMice, Inbred C57BLMice, Inbred mdxMicroRNAsMuscle DevelopmentMuscle Fibers, SkeletalMuscle, SkeletalMuscular Dystrophy, AnimalPhosphorylationPhosphoserineSrc Homology 2 Domain-Containing, Transforming Protein 1MicroRNAsMirn200 microRNA, mousePhosphoserineSrc Homology 2 Domain-Containing, Transforming Protein 1

Identifiers

PMID29636844
PMCPMC5831318
OpenAlexW2791497460

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.