Evidence map›Paper›PMID 29636834›Full record

ArticleClinical epigenetics2018

Allele-specific methylation in the

Elaheh Rahbar, Charlotte Mae K Waits, Edward H Kirby, Leslie R Miller, Hannah C Ainsworth, Tao Cui, Susan Sergeant, Timothy D Howard, Carl D Langefeld, Floyd H Chilton

Open access · goldAbstract read
In one paragraph

Article in Clinical epigenetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 32 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Observational
  9. Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Elaheh Rahbar1Department of Biomedical Engineering, Wake Forest University School of Medicine, Virginia-Tech Wake Forest School of Biomedical Engineering and Sciences, 575 N. Patterson Ave. Suite 120, Winston-Salem, NC 27101 USA.
Charlotte Mae K Waits1Department of Biomedical Engineering, Wake Forest University School of Medicine, Virginia-Tech Wake Forest School of Biomedical Engineering and Sciences, 575 N. Patterson Ave. Suite 120, Winston-Salem, NC 27101 USA.
Edward H Kirby1Department of Biomedical Engineering, Wake Forest University School of Medicine, Virginia-Tech Wake Forest School of Biomedical Engineering and Sciences, 575 N. Patterson Ave. Suite 120, Winston-Salem, NC 27101 USA.
Leslie R Miller3Department of Physiology and Pharmacology, Wake Forest School of Medicine, 575 N. Patterson Ave. Suite 310, Winston-Salem, NC 27101 USA.
Hannah C Ainsworth4Department of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest School of Medicine, Medical Center Blvd/525 Vine Street, Winston-Salem, NC 27157-1063 USA.
Tao Cui5Department of Urology, Wake Forest School of Medicine, 1 Medical Center Blvd, Winston-Salem, NC 27157 USA.
Susan Sergeant6Department of Biochemistry, Wake Forest School of Medicine, 1 Medical Center Blvd, Winston-Salem, NC 27157 USA.
Timothy D Howard6Department of Biochemistry, Wake Forest School of Medicine, 1 Medical Center Blvd, Winston-Salem, NC 27157 USA.
Carl D Langefeld4Department of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest School of Medicine, Medical Center Blvd/525 Vine Street, Winston-Salem, NC 27157-1063 USA.
Floyd H Chilton3Department of Physiology and Pharmacology, Wake Forest School of Medicine, 575 N. Patterson Ave. Suite 310, Winston-Salem, NC 27101 USA.
Wake Forest University · USVirginia Tech - Wake Forest University School of Biomedical Engineering & Sciences · US

Funding

The Wake Forest Center for Botanical Lipids and Inflammatory Disease PreventionP50AT002782 · NCCIH · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI CHILTON, FLOYD H · 2005 to 2014
$15.3M
Role of PUFA-Gene Interactions in Health DisparitiesR01AT008621 · NCCIH · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI FLOYD H CHILTON, Susan Schembre · 2016 to 2026
$5.4M
An Integrated Investigation of the Interaction Between PUFAs and Genetic Variants in Trauma and Critical CareK25HL133611 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI RAHBAR, ELAHEH · 2017 to 2021
$841k
NCCIH NIH HHS P50 AT002782NCCIH NIH HHS R01 AT008621NHLBI NIH HHS K25 HL133611
6 · The paper itself

Abstract

Background: Genetic variants within the fatty acid desaturase ( Results: DNA methylation at six CpG sites spanning Conclusions: We observed significant ASM between rs174537 and DNA methylation at key regulatory regions in the

Indexed as

DNA MethylationAdultAllelesCD4-Positive T-LymphocytesChromosomes, Human, Pair 11Delta-5 Fatty Acid DesaturaseFatty Acid DesaturasesFemaleHealthy VolunteersHumansLeukocytesMaleMiddle AgedOrgan SpecificitySalivaWhite PeopleDelta-5 Fatty Acid DesaturaseFADS1 protein, humanFatty Acid DesaturasesCD4+DNA methylationFADSLeukocytesOmega-6PUFArs174537SalivaWhole blood

Identifiers

PMID29636834
PMCPMC5889567
OpenAlexW2796661518

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.