ArticleEvidence-based complementary and alternative medicine : eCAM2018
Antitumor Mechanisms of Curcumae Rhizoma Based on Network Pharmacology.
Article in Evidence-based complementary and alternative medicine : eCAM, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Role ofArchives of Razi Institute · 2024Article
- Mechanisms of Er Chen Tang on Treating Asthma Explored by Network Pharmacology and Experimental Verification.Combinatorial chemistry & high throughput screening · 2024Article
- Article
- Astragalus membranaceus (Huangqi) and Rhizoma curcumae (Ezhu) decoction suppresses colorectal cancer via downregulation of Wnt5/β-Catenin signal.Chinese medicine · 2022Article
- Systematic elucidation of the mechanism of Jingyin granule in the treatment of Novel Coronavirus (COVID-19) Pneumonia via Network Pharmacology.International journal of medical sciences · 2021Article
- Exploration of the Modulatory Property Mechanism of ELeng Capsule in the Treatment of Endometriosis Using Transcriptomics Combined With Systems Network Pharmacology.Frontiers in pharmacology · 2021Article
- Natural Product-Based Studies for the Management of Castration-Resistant Prostate Cancer: Computational to Clinical Studies.Frontiers in pharmacology · 2021Review
- Network Pharmacology and Molecular Docking Suggest the Mechanism for Biological Activity of Rosmarinic Acid.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- A network pharmacology-based approach to explore potential targets of Caesalpinia pulcherima: an updated prototype in drug discovery.Scientific reports · 2020Article
- Anticancer Effect of Radix Astragali on Cholangiocarcinoma In Vitro and Its Mechanism via Network Pharmacology.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- Research on the Potential Mechanism of Gentiopicroside Against Gastric Cancer Based on Network Pharmacology.Drug design, development and therapy · 2020Article
- Modular Characteristics and Mechanism of Action of Herbs for Endometriosis Treatment in Chinese Medicine: A Data Mining and Network Pharmacology-Based Identification.Frontiers in pharmacology · 2020Article
- Germacrone Induces Apoptosis as Well as Protective Autophagy in Human Prostate Cancer Cells.Cancer management and research · 2020Article
- Systematic Elucidation of the Mechanism ofEvidence-based complementary and alternative medicine : eCAM · 2020Article
- Based on network pharmacology to explore the molecular mechanisms of astragalus membranaceus for treating T2 diabetes mellitus.Annals of translational medicine · 2019Article
- Systematic elucidation of the mechanism of geraniol via network pharmacology.Drug design, development and therapy · 2019Article
- Role of curcumin in regulating p53 in breast cancer: an overview of the mechanism of action.Breast cancer (Dove Medical Press) · 2018Review
Corrections and comments
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Authors and funding
4 authors.
Funding
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Abstract
Curcumae Rhizoma, a traditional Chinese medication, is commonly used in both traditional treatment and modern clinical care. Its anticancer effects have attracted a great deal of attention, but the mechanisms of action remain obscure. In this study, we screened for the active compounds of Curcumae Rhizoma using a drug-likeness approach. Candidate protein targets with functions related to cancer were predicted by reverse docking and then checked by manual search of the PubMed database. Potential target genes were uploaded to the GeneMANIA server and DAVID 6.8 database for analysis. Finally, compound-target, target-pathway, and compound-target-pathway networks were constructed using Cytoscape 3.3. The results revealed that the anticancer activity of Curcumae Rhizoma potentially involves 13 active compounds, 33 potential targets, and 31 signaling pathways, thus constituting a "multiple compounds, multiple targets, and multiple pathways" network corresponding to the concept of systematic actions in TCM. These findings provide an overview of the anticancer action of Curcumae Rhizoma from a network perspective, as well as setting an example for future studies of other materials used in TCM.
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Registered trials
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