Evidence map›Paper›PMID 29636753›Full record

ArticleFrontiers in immunology2018

Elevated Level of CD4

Huan Xia, Wei Jiang, Xin Zhang, Ling Qin, Bin Su, Zhen Li, Jianping Sun, Yonghong Zhang, Tong Zhang, Xiaofan Lu and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 22 citations in OpenAlex.

  1. CD169Frontiers in cellular and infection microbiology · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Tryptophan potentiates CD8Journal for immunotherapy of cancer · 2021
    Article
  10. Review
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Huan XiaBeijing Key Laboratory for HIV/AIDS Research, Center for Infectious Diseases, Beijing You'an Hospital, Capital Medical University, Beijing, China.
Wei JiangDepartment of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, United States.
Xin ZhangBeijing Key Laboratory for HIV/AIDS Research, Center for Infectious Diseases, Beijing You'an Hospital, Capital Medical University, Beijing, China.
Ling QinBiomarkers of Infection Related Diseases, Beijing Key Laboratory, Beijing You'an Hospital, Capital Medical University, Beijing, China.
Bin SuBeijing Key Laboratory for HIV/AIDS Research, Center for Infectious Diseases, Beijing You'an Hospital, Capital Medical University, Beijing, China.
Zhen LiBeijing Key Laboratory for HIV/AIDS Research, Center for Infectious Diseases, Beijing You'an Hospital, Capital Medical University, Beijing, China.
Jianping SunBiomarkers of Infection Related Diseases, Beijing Key Laboratory, Beijing You'an Hospital, Capital Medical University, Beijing, China.
Yonghong ZhangBiomarkers of Infection Related Diseases, Beijing Key Laboratory, Beijing You'an Hospital, Capital Medical University, Beijing, China.
Tong ZhangBeijing Key Laboratory for HIV/AIDS Research, Center for Infectious Diseases, Beijing You'an Hospital, Capital Medical University, Beijing, China.
Xiaofan LuBeijing Key Laboratory for HIV/AIDS Research, Center for Infectious Diseases, Beijing You'an Hospital, Capital Medical University, Beijing, China.
Hao WuBeijing Key Laboratory for HIV/AIDS Research, Center for Infectious Diseases, Beijing You'an Hospital, Capital Medical University, Beijing, China.
Beijing YouAn Hospital · CNCapital Medical University · CNMedical University of South Carolina · US

Funding

Synergistic effect of HIV virions and bacterial LPS on memory B cell apoptosisR01AI091526 · NIAID · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI JIANG, WEI · 2011 to 2015
$1.4M
On the pathogenic role of anti-CD4 antibody in poor CD4+ T cell recovery after antiretroviral therapy in HIV diseaseR01AI128864 · NIAID · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI JIANG, WEI · 2017 to 2021
$1.1M
NIAID NIH HHS R01 AI091526NIAID NIH HHS R01 AI128864
6 · The paper itself

Abstract

Persistent immune activation is a striking consequence of HIV-1 infection and a driving force of CD4

Indexed as

Acute DiseaseBeijingCD4 Lymphocyte CountCD4-Positive T-LymphocytesCell SurvivalCohort StudiesHIV-1HIV InfectionsHumansInterleukin-2Ki-67 AntigenLymphocyte ActivationMaleProgrammed Cell Death 1 ReceptorProspective StudiesInterleukin-2Ki-67 AntigenProgrammed Cell Death 1 Receptoracute HIV-1 infectionCD4+ T cellimmune exhaustion moleculesT cell immune activationT cell preservation

Identifiers

PMID29636753
PMCPMC5880913
OpenAlexW2796503167

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.