ArticleFrontiers in psychiatry2018
A Randomized Controlled Trial Comparing Behavioral, Educational, and Pharmacological Treatments in Youths With Chronic Tic Disorder or Tourette Syndrome.
Article in Frontiers in psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03621059 (Behavioral Therapy for Children and Adolescents With Tourette Syndrome), which is not on this map. Cited by 29 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Behavioral Therapy for Children and Adolescents With Tourette Syndrome: A Randomized Controlled Trial in Taiwan
Who cites it
29 citing papers in PubMed, 3 syntheses or guidelines pooled it, 78 citations in OpenAlex.
- European clinical guidelines for Tourette syndrome and other tic disorders-version 2.0. Part II: psychological interventions.European child & adolescent psychiatry · 2022Guideline
- The Efficacy of Cognitive Behavioral Therapy for Tic Disorder: A Meta-Analysis and a Literature Review.Frontiers in psychology · 2022Pooled it
- Profiles of Proinflammatory Cytokines and T Cells in Patients With Tourette Syndrome: A Meta-Analysis.Frontiers in immunology · 2022Pooled it
- Mindful energy balance exercise protocol as an adjunctive intervention for pediatric tourette syndrome: A randomized controlled trial.Scientific reports · 2025Trial
- Online remote behavioural intervention for tics in 9- to 17-year-olds: the ORBIT RCT with embedded process and economic evaluation.Health technology assessment (Winchester, England) · 2023Trial
- Group behavioral interventions for tics and comorbid symptoms in children with chronic tic disorders.European child & adolescent psychiatry · 2022Trial
- Use of Nutritional Supplements Based on L-Theanine and Vitamin B6 in Children with Tourette Syndrome, with Anxiety Disorders: A Pilot Study.Nutrients · 2022Trial
- Efficacy of Clonidine Adhesive Patch for Patients With Tourette Syndrome: A Randomized, Double-blind, Placebo-Controlled, Multicenter Clinical Trial.Clinical neuropharmacologyTrial
- Tourette syndrome.Nature reviews. Disease primers · 2026Review
- Medication use and treatment patterns in children and adolescents with chronic tic disorders: an EMTICS study.European child & adolescent psychiatry · 2026Article
- Contemporary Perspectives on Neurobiology and Treatment of Tic Disorders: A Narrative Review.Journal of the Korean Academy of Child and Adolescent Psychiatry · 2026Article
- Digital-Supported Delivery of Behavioural Therapy for Patients with Tic Disorders: A Narrative Review.Brain sciences · 2026Review
- Pain in Tourette Syndrome: A Comprehensive Review.Journal of child and adolescent psychopharmacology · 2025Review
- Therapeutic Approach to Primary Tic Disorders and Associated Psychiatric Comorbidities.Brain sciences · 2024Article
- Deep brain stimulation for Tourette's syndrome.The Cochrane database of systematic reviews · 2024Article
- Exposure and response prevention versus risperidone for the treatment of tic disorders: a randomized controlled trial.Frontiers in psychiatry · 2024Article
- Exploring protocol development: Implementing systematic contextual memory to enhance real-time fMRI neurofeedback.Journal of electrical bioimpedance · 2024Article
- Cognitive and Neural Mechanisms of Behavior Therapy for Tics: A Perception-Action Integration Approach.Biomedicines · 2023Review
- Tourette syndrome: clinical features, pathophysiology, and treatment.The Lancet. Neurology · 2023Review
- European clinical guidelines for Tourette syndrome and other tic disorders-version 2.0. Part III: pharmacological treatment.European child & adolescent psychiatry · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextThe existing literature on the treatment of pediatric chronic tic disorder (CTD) and Tourette syndrome (TS) indicates that both behavioral therapy (BT) and pharmacotherapy (PT) are effective for reducing symptoms.
objectiveTo evaluate the efficacy of BT compared to psychoeducation (PE) or PT for reducing tics and co-occurring symptoms and for improving quality of life (QoL) in a sample of youths with CTD and TS.
designA 10 weeks, 2 sites (Catania, Rome) randomized controlled trial. Participants were randomized to receive one of the following treatments: BT, PE, or PT.
participants110 outpatients aged between 8 and 17 years affected by CTD or TS.
resultsPatients in the BT and PT groups showed a significant reduction in the severity of tic symptoms, while the PE group did not show any improvement. PT was more effective for reducing obsessive compulsive symptoms than BT, while PE group did not show any improvement. Both BT and PT groups showed an improvement in most QoL domains, whereas no differences were found in the PE group.
conclusionsBT is as effective as pharmacological therapy in the treatment of tic disorders in children and adolescents, thus offering an alternative to medications for CTD and TS.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.