ArticleJournal of pain research2018
The impact of anxiety and catastrophizing on interleukin-6 responses to acute painful stress.
Article in Journal of pain research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04902196 (Acute Effects of a High Intensity Training Protocol on Pain Processing and Inflammatory Parameters in Persons With Chronic Nonspecific Low Back Pain.), which is not on this map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Acute Effects of a High Intensity Training Protocol on Pain Processing and Inflammatory Parameters in Persons With Chronic Nonspecific Low Back Pain.
Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
- Immune-neural crosstalk in chronic low back pain: from intervertebral disc degeneration to pain sensitization.Frontiers in immunology · 2026Review
- Psychological and immunological associations with movement-evoked low back pain among older adults.Pain reports · 2025Article
- Context is Complex: Challenges and opportunities addressing contextual factors in manual therapy mechanisms research.International journal of osteopathic medicine : IJOM · 2025Article
- Negative affect and pain catastrophizing link borderline personality disorder to pain: Replicating and extending the borderline personality disorder-pain association.Personality disorders · 2025Article
- The Mediating Role of Anger and Anxiety in the Association of Social Support with Mobility Among Middle-Age and Older Adults with Knee Osteoarthritis.International journal of environmental research and public health · 2025Article
- Comparison of Pain, Cortisol, and IL6 Levels Pre and Post SEFT in Stage III B Cervical Cancer Patients.Asian Pacific journal of cancer prevention : APJCP · 2025Article
- The association between changes in clinical pain severity and IL-6 reactivity among patients undergoing total knee Arthroplasty: The moderating role of change in insomnia.Brain, behavior, and immunity · 2024Article
- Through the Lens of Movement-Evoked Pain: A Theoretical Framework of the "Pain-Movement Interface" to Guide Research and Clinical Care for Musculoskeletal Pain Conditions.The journal of pain · 2024Review
- Mindfulness in Facilitating Pelvic Floor Botulinum Toxin Injection in Women with Chronic Pelvic Pain.Toxins · 2024Article
- Circulating Inflammatory Biomarkers Predict Pain Change Following Exercise-Induced Shoulder Injury: Findings From the Biopsychosocial Influence on Shoulder Pain Preclinical Trial.The journal of pain · 2023Article
- Toward the unknown: consciousness and pain.Neuroscience of consciousness · 2023Article
- COVID-19 Vaccination in Young People with Functional Neurological Disorder: A Case-Control Study.Vaccines · 2022Article
- Article
- Quantitative sensory testing in children with sickle cell disease: additional insights and future possibilities.British journal of haematology · 2019Article
- Sex Differences in Interleukin-6 Responses Over Time Following Laboratory Pain Testing Among Patients With Knee Osteoarthritis.The journal of painArticle
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo examine the influence of anxiety and pain-related catastrophizing on the time course of acute interleukin-6 (IL-6) responses to standardized noxious stimulation among patients with chronic pain.
methodsData were collected from 48 participants in the following demographically matched groups: patients with chronic pain (n=36) and healthy controls (n=12). Participants underwent a series of Quantitative Sensory Testing (QST) procedures assessing responses to mechanical and thermal stimuli during two separate visits, in a randomized order. One visit consisted of standard, moderately painful QST procedures, while the other visit involved nonpainful analogs to these testing procedures. Blood samples were taken at baseline, and then for up to 2 hours after QST in order to study the time course of IL-6 responses.
resultsResults of multilevel analyses revealed that IL-6 responses increased across assessment time points in both visits (
conclusionUnder specific conditions (eg, application of a painful stressor), catastrophizing may be associated with amplified proinflammatory responses in patients with persistent pain. These findings suggest that psychosocial interventions that reduce negative pain-related cognitions may benefit patients' inflammatory profiles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.