Evidence map›Paper›PMID 29636625›Full record

ArticleInfection and drug resistance2017

Overproduction of efflux pumps caused reduced susceptibility to carbapenem under consecutive imipenem-selected stress in

Yanpeng Zhang, Zhuocheng Li, Xiaolong He, Fanglin Ding, Weiqing Wu, Yong Luo, Bing Fan, Hong Cao

Open access · goldAbstract read
In one paragraph

Article in Infection and drug resistance, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
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  6. Review
  7. Article
  8. Article
  9. Genetic profiling of multidrug-resistantMicrobiology spectrum · 2025
    Article
  10. Article
  11. Efflux-Related Carbapenem Resistance inInternational journal of molecular sciences · 2023
    Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Molecular Characterization of Carbapenem-ResistantInfection and drug resistance · 2022
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yanpeng ZhangDepartment of Microbiology, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, 510515, China.
Zhuocheng LiLaboratory Department of the First Affiliated Hospital of Shenzhen University, Shenzhen, 518000, China.
Xiaolong HeDepartment of Microbiology, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, 510515, China.
Fanglin DingLaboratory Department of the First Affiliated Hospital of Shenzhen University, Shenzhen, 518000, China.
Weiqing WuLaboratory Department of the First Affiliated Hospital of Shenzhen University, Shenzhen, 518000, China.
Yong LuoLaboratory Department of the First Affiliated Hospital of Shenzhen University, Shenzhen, 518000, China.
Bing FanLaboratory Department of the First Affiliated Hospital of Shenzhen University, Shenzhen, 518000, China.
Hong CaoDepartment of Microbiology, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, 510515, China.
Shenzhen University · CNSouthern Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePATIENTS AND

methodsIn this study, an imipenem-susceptible clinical isolate was identified as

resultsUnder consecutive imipenem-selected stress, the MIC to imipenem increased gradually from 0.125 μg/mL to 8 μg/mL. The effect of resistance inducement was almost neutralized when treated with an efflux pump inhibitor. The expression of efflux pumps,

conclusionIn conclusion, under consecutive imipenem-selected stress in vitro,

Indexed as

Acinetobacter baumanniiefflux pumpimipenemmultidrug resistanceouter membrane protein

Identifiers

PMID29636625
PMCPMC5880185
OpenAlexW2794648012

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.