ArticleNeuropsychiatric disease and treatment2018
Investigation of variants in estrogen receptor genes and perinatal depression.
Article in Neuropsychiatric disease and treatment, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Perinatal Depression: Current Knowledge.Advances in experimental medicine and biology · 2026Review
- The complex interaction between oestrogen receptor genes, oestradiol, and perinatal mood.Dialogues in clinical neuroscience · 2025Article
- Association of estrogen receptor single nucleotide polymorphisms and perinatal depression.PloS one · 2025Article
- Genome-wide association study of early-onset and late-onset postpartum depression: the IGEDEPP prospective study.European psychiatry : the journal of the Association of European Psychiatrists · 2024Article
- Association of Perinatal Depressive Symptoms with Breastfeeding.Alpha psychiatry · 2024Article
- Genetic Markers Associated with Postpartum Depression: A Review.Neuropsychiatric disease and treatment · 2024Review
- Deciphering and Targeting the ESR2-miR-10a-5p-BDNF Axis in the Prefrontal Cortex: Advancing Postpartum Depression Understanding and Therapeutics.Research (Washington, D.C.) · 2024Article
- Risk Factors for Postpartum Depression Based on Genetic and Epigenetic Interactions.Molecular neurobiology · 2023Review
- Genetic variants in the genes of the sex steroid hormone metabolism and depressive symptoms during and after pregnancy.Archives of gynecology and obstetrics · 2023Article
- Association Between Polymorphisms in Estrogen Receptor Genes and Depression in Women: A Meta-Analysis.Frontiers in genetics · 2022Article
- Shared genetic liability between major depressive disorder and osteoarthritis.Bone & joint research · 2022Article
- Exploring the Mechanism of Action of Herbal Medicine (Evidence-based complementary and alternative medicine : eCAM · 2021Article
- The association between hormones and antipsychotic use: a focus on postpartum and menopausal women.Therapeutic advances in psychopharmacology · 2019Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesDepressive symptoms are common during pregnancy and after childbirth. Estrogen levels fluctuate greatly during the course of pregnancy and may contribute to mood instability. The first aim of this case-control study was to investigate whether variants in the two estrogen receptor genes might contribute to the genetic susceptibility to pregnancy-related depression using controls that were screened for postnatal depression. The second aim was to uncover new variants in the two estrogen receptor genes. PATIENTS AND
methodsOur study sample comprised 554 control subjects who had Edinburgh Postnatal Depression Scale (EPDS) scores below 7 at postnatal screening, and 159 patients with clinically diagnosed pregnancy-related depression. They were genotyped for four single-nucleotide polymorphisms (SNPs) and a dinucleotide repeat in the two genes: estrogen receptor α (
resultsThere was no statistically significant association with perinatal depression for all five variants. However, there was a trend toward higher frequencies of the genotypes associated with higher risk of depression for rs2077647 and rs4986938 in the case group. From resequencing, two novel
conclusionOur study that used screened controls with low EPDS scores and cases with clinically diagnosed pregnancy-related depression could not replicate the association with depression for any of the SNPs for both genotype and allele frequencies. Two novel SNPs were identified and could be further investigated in a larger sample set.
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