Evidence map›Paper›PMID 29636555›Full record

ReviewNature reviews. Gastroenterology & hepatology2018

Expert consensus document: Advances in the evaluation of anorectal function.

Emma V Carrington, S Mark Scott, Adil Bharucha, François Mion, Jose M Remes-Troche, Allison Malcolm, Henriette Heinrich, Mark Fox, Satish S Rao, International Anorectal Physiology Working Group and the International Working Group for Disorders of Gastrointestinal Motility and Function

3 registry-linked trialsAbstract readReviewConsensus Statement
In one paragraph

Review in Nature reviews. Gastroenterology & hepatology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 83 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05185609 recruitingnot on this mapstarted 2021, after this paper: background citation

Assessment of Anorectal Function in Healthy Volunteers and Patients With Inflammatory Bowel Disease

TypeobservationalSponsorRegion Örebro CountyRan2021 to 2027Enrolled70ConditionsInflammatory Bowel Diseases, Irritable Bowel SyndromeArmsExposure 1: Visceral hypersensitivity or phenotype suggestive of IBS, Exposure 2: Changes in anorectal motor function or compliance.
NCT05351034 naunknown statusnot on this mapstarted 2022, after this paper: background citation

The Role of High-resolution Anorectal Manometry in the Diagnosis of Functional Anorectal Disorders in Patients With Inactive Inflammatory Bowel Disease

TypeinterventionalSponsorAssiut UniversityRan2022 to 2024Enrolled50ConditionsInflammatory Bowel DiseasesArmsAnorectal manometry
NCT07291661 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

The Role of Anorectal Manometry in Diagnosing and Guiding Management of Pediatric Chronic Refractory Constipation

TypeinterventionalSponsorAssiut UniversityRan2026 to 2027Enrolled54ConditionsRefractory Constipation, Fecal Incontinence in ChildrenArmsHigh resolution anorectal manometry using a multiuse water perfused catheter
3 · Its place in the literature

Who cites it

83 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Guideline
  3. Guideline
  4. Trial
  5. Trial
  6. Trial
  7. High-resolution anorectal manometry in chronic constipation-Defining dysfunction beyond diagnosis.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Observational
  13. Ileal bile acid transporter inhibitors for chronic constipation in the elderly.World journal of gastrointestinal pharmacology and therapeutics · 2026
    Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Flat Magnetic Stimulation for Anal Incontinence: A Prospective Study.International journal of women's health · 2025
    Article
  19. Article
  20. Review

23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Emma V CarringtonNational Bowel Research Centre, Blizard Institute, Queen Mary University of London, London, UK.
S Mark ScottNational Bowel Research Centre, Blizard Institute, Queen Mary University of London, London, UK.
Adil BharuchaDepartment of Gastroenterology and Hepatology, Mayo College of Medicine, Rochester, MN, USA.
François MionExploration Fonctionnelle Digestive, Hospital Edouard Herriot, Hospices Civils de Lyon, Lyon I University and Inserm 1032 LabTAU, Lyon, France.
Jose M Remes-TrocheLaboratorio de Fisiología Digestiva y Motilidad Gastrointestinal, Instituto de Investigaciones Médico Biológicas, Universidad Veracruzana, Veracruz, México.
Allison MalcolmDivision of Gastroenterology, Royal North Shore Hospital, and University of Sydney, Sydney, Australia.
Henriette HeinrichNational Bowel Research Centre, Blizard Institute, Queen Mary University of London, London, UK.
Mark FoxAbdominal Center: Gastroenterology, St. Claraspital, Basel, Switzerland.
Satish S RaoDivision of Gastroenterology and Hepatology, Augusta University, Augusta, GA, USA.
International Anorectal Physiology Working Group and the International Working Group for Disorders of Gastrointestinal Motility and Function

Funding

Pathophysiology of Anorectal DisordersR01DK078924 · NIDDK · MAYO CLINIC ROCHESTER · PI BHARUCHA, ADIL E. · 2008 to 2023
$5.0M
NIDDK NIH HHS R01 DK078924
6 · The paper itself

Abstract

Faecal incontinence and evacuation disorders are common, impair quality of life and incur substantial economic costs worldwide. As symptoms alone are poor predictors of underlying pathophysiology and aetiology, diagnostic tests of anorectal function could facilitate patient management in those cases that are refractory to conservative therapies. In the past decade, several major technological advances have improved our understanding of anorectal structure, coordination and sensorimotor function. This Consensus Statement provides the reader with an appraisal of the current indications, study performance characteristics, clinical utility, strengths and limitations of the most widely available tests of anorectal structure (ultrasonography and MRI) and function (anorectal manometry, neurophysiological investigations, rectal distension techniques and tests of evacuation, including defecography). Additionally, this article provides our consensus on the clinical relevance of these tests.

Indexed as

Anal CanalAnus DiseasesFecal IncontinenceHumansRectal DiseasesRectum

Identifiers

PMID29636555
PMCPMC6028941

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.