ArticleScientific reports2018
GC-MS-based urinary organic acid profiling reveals multiple dysregulated metabolic pathways following experimental acute alcohol consumption.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 24 citations in OpenAlex.
- Metabolomic Profiling of Serum Reveals Energy Metabolism Differences in Nellore Bulls with Divergent Growth Rates during Feedlot Finishing.ACS omega · 2025Article
- Protein lysine four-carbon acylations in health and disease.Journal of cellular physiology · 2024Review
- Clinical and Gene Analysis of Fatty Acid Oxidation Disorders Found in Neonatal Tandem Mass Spectrometry Screening.Pharmacogenomics and personalized medicine · 2023Article
- Characteristics of Normalization Methods in Quantitative Urinary Metabolomics-Implications for Epidemiological Applications and Interpretations.Biomolecules · 2022Article
- 2-hydroxyisobutyric acid (2-HIBA) modulates ageing and fat deposition inFrontiers in molecular biosciences · 2022Article
- The First Case Report of X-Linked Sideroblastic Anemia With Ataxia of Chinese Origin and Literature Review.Frontiers in pediatrics · 2021Article
- Prediction of Autoimmune Diseases by Targeted Metabolomic Assay of Urinary Organic Acids.Metabolites · 2020Article
- Epigenetic mechanisms underlying pathobiology of alcohol use disorder.Current pathobiology reports · 2020Article
- Article
- Actinobacterial Degradation of 2-Hydroxyisobutyric Acid Proceeds via Acetone and Formyl-CoA by Employing a Thiamine-Dependent Lyase Reaction.Frontiers in microbiology · 2020Article
- Review of recent developments in GC-MS approaches to metabolomics-based research.Metabolomics : Official journal of the Metabolomic Society · 2018Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metabolomics studies of diseases associated with chronic alcohol consumption provide compelling evidence of several perturbed metabolic pathways. Moreover, the holistic approach of such studies gives insights into the pathophysiological risk factors associated with chronic alcohol-induced disability, morbidity and mortality. Here, we report on a GC-MS-based organic acid profiling study on acute alcohol consumption. Our investigation - involving 12 healthy, moderate-drinking young men - simulated a single binge drinking event, and indicated its metabolic consequences. We generated time-dependent data that predicted the metabolic pathophysiology of the alcohol intervention. Multivariate statistical modelling was applied to the longitudinal data of 120 biologically relevant organic acids, of which 13 provided statistical evidence of the alcohol effect. The known alcohol-induced increased NADH:NAD
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