ArticleNature communications2018
A NIGT1-centred transcriptional cascade regulates nitrate signalling and incorporates phosphorus starvation signals in Arabidopsis.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 130 papers.
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130 citing papers in PubMed, 329 citations in OpenAlex.
- Active ROP2 triggers leaf senescence and orchestrates the growth-senescence trade-off under nitrogen starvation.Plant signaling & behavior · 2026Article
- NLP6/7-mediated nitrate signaling facilitates high-affinity potassium uptake and enhances tolerance to low potassium environments in Arabidopsis.The Plant journal : for cell and molecular biology · 2026Article
- CsSPX-PHR/PHL-PHT1 and CsmiR399a-PHO2-PHT1/PHO1 Modules Orchestrate Pi Use Efficiency and Aluminium Tolerance in Tea Plants.Plant, cell & environment · 2026Article
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- Mineral nutrients as regulators of plant flowering time: A molecular perspective.Journal of integrative plant biology · 2026Review
- Sentinel plants enable quantitative monitoring of bioavailable nitrate in soils and microbial environments.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Cytokinin receptor AHK3 influences leaf size by modulating trans-zeatin-type cytokinin levels in xylem.Plant & cell physiology · 2026Article
- Identification of symbiotic nitrogen fixation-modulating factors in alfalfa and mechanism elucidation of MsHHO3.The Plant journal : for cell and molecular biology · 2026Article
- TaPHL7 Transcription Factor Regulates Utilisation of Nitrogen and Phosphorus in Wheat.Plant biotechnology journal · 2026Article
- PPSR1 Protein Functions as an Important Regulator to Enhance Plant Growth Performance Under N, P, and K Deficient Stress Conditions.Plant biotechnology journal · 2026Article
- Progress and new questions in understanding the mechanisms controlling plant nitrogen responses.Plant biotechnology (Tokyo, Japan) · 2026Article
- Integrated Gene Regulatory Network Analysis Reveals Coordinated Transcriptional Reprogramming in thePlants (Basel, Switzerland) · 2026Article
- Arbuscular Mycorrhizal Fungi-Mediated Reconfiguration of Poplar Leaf C-N-P Metabolic Networks: Environment-Dependent Synergies and Nutrient Interactions.Journal of fungi (Basel, Switzerland) · 2026Article
- Adaptation mechanisms of low-phosphorus stress in plants: physiological responses, molecular regulation, and future perspectives.Frontiers in plant science · 2026Review
- Cytokinin availability and chloroplast functional lifetime in senescing leaves.Frontiers in plant science · 2026Review
- NRT1.1 as central signaling hub orchestrating plant growth and stress trade-offs.Frontiers in plant science · 2026Review
- Rapid acquisition of ionomic and morphological data from plant seeds through fast X-ray fluorescence microscopy and computer vision.Plant phenomics (Washington, D.C.) · 2025Article
- Fluctuations in nitrate availability impact cytokinin biosynthesis through histone modifications of IPT3 in Arabidopsis roots for growth acclimation.Plant communications · 2025Article
- Companion cells with high florigen production express other small proteins and reveal a nitrogen-sensitiveeLife · 2025Article
70 more citing papers are in PubMed but not listed here.
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9 authors at 2 institutions in 1 country.
Funding
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Abstract
Nitrate is a nutrient signal that triggers complex regulation of transcriptional networks to modulate nutrient-dependent growth and development in plants. This includes time- and nitrate concentration-dependent regulation of nitrate-related gene expression. However, the underlying mechanisms remain poorly understood. Here we identify NIGT1 transcriptional repressors as negative regulators of the Arabidopsis NRT2.1 nitrate transporter gene, and show antagonistic regulation by NLP primary transcription factors for nitrate signalling and the NLP-NIGT1 transcriptional cascade-mediated repression. This antagonistic regulation provides a resolution to the complexity of nitrate-induced transcriptional regulations. Genome-wide analysis reveals that this mechanism is applicable to NRT2.1 and other genes involved in nitrate assimilation, hormone biosynthesis and transcription. Furthermore, the PHR1 master regulator of the phosphorus-starvation response also directly promotes expression of NIGT1 family genes, leading to reductions in nitrate uptake. NIGT1 repressors thus act in two transcriptional cascades, forming a direct link between phosphorus and nitrogen nutritional regulation.
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