Evidence map›Paper›PMID 29636440›Full record

ArticlemBio2018

A Biofilm Matrix-Associated Protease Inhibitor Protects Pseudomonas aeruginosa from Proteolytic Attack.

Boo Shan Tseng, Courtney Reichhardt, Gennifer E Merrihew, Sophia A Araujo-Hernandez, Joe J Harrison, Michael J MacCoss, Matthew R Parsek

Open access · goldAbstract read
In one paragraph

Article in mBio, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 89 citations in OpenAlex.

  1. Targeting Outer Membrane Vesicles ofJournal of microbiology and biotechnology · 2026
    Review
  2. Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Microbial Primer: The catalytic biofilm matrix.Microbiology (Reading, England) · 2024
    Review
  7. FTY720 Reduces the Biomass of Biofilms inAntibiotics (Basel, Switzerland) · 2024
    Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. OprF impactsbioRxiv : the preprint server for biology · 2023
    Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Gastrointestinal biofilms in health and disease.Nature reviews. Gastroenterology & hepatology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Boo Shan Tseng *Department of Microbiology, University of Washington, Seattle, Washington, USA boo.tseng@unlv.edu parsem@uw.edu.
Courtney Reichhardt *Department of Microbiology, University of Washington, Seattle, Washington, USA.
Gennifer E MerrihewDepartment of Genome Sciences, University of Washington, Seattle, Washington, USA.
Sophia A Araujo-HernandezSchool of Life Sciences, University of Nevada Las Vegas, Las Vegas, Nevada, USA.
Joe J HarrisonDepartment of Biological Sciences, University of Calgary, Calgary, AB, Canada.
Michael J MacCossDepartment of Genome Sciences, University of Washington, Seattle, Washington, USA.
Matthew R ParsekDepartment of Microbiology, University of Washington, Seattle, Washington, USA boo.tseng@unlv.edu parsem@uw.edu.
University of Washington · USUniversity of Nevada, Las Vegas · USUniversity of Calgary · CA

Funding

Translational Research Center to Expedite Novel Therapies in Cystic FibrosisP30DK089507 · NIDDK · SEATTLE CHILDREN'S HOSPITAL · PI PRADEEP k SINGH · 2010 to 2026
$21.4M
TrainingP41GM103533 · NIGMS · UNIVERSITY OF WASHINGTON · PI YATES III, JOHN R · 2012 to 2021
$20.7M
The pel exopolysaccharide gene cluster of Pseudomonas aeruginosaR01AI077628 · NIAID · UNIVERSITY OF WASHINGTON · PI MATTHEW R. PARSEK, Daniel J Wozniak · 2009 to 2026
$7.1M
Pseudomonas biofilms and immunityR01AI097511 · NIAID · OHIO STATE UNIVERSITY · PI WOZNIAK, DANIEL J · 2013 to 2017
$1.9M
Matrix-associated proteins in biofilm tolerance: Psl and ecotinK22AI121097 · NIAID · UNIVERSITY OF NEVADA LAS VEGAS · PI TSENG, BOO SHAN · 2016 to 2017
$268k
NIAID NIH HHS K22 AI121097NIAID NIH HHS R01 AI077628NIAID NIH HHS R01 AI097511NIDDK NIH HHS P30 DK089507NIGMS NIH HHS P41 GM103533
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Anti-Bacterial AgentsBiofilmsExtracellular Polymeric Substance MatrixLeukocyte ElastaseMicrobial ViabilityPeriplasmic ProteinsPseudomonas aeruginosaAnti-Bacterial Agentsecotin protein, Pseudomonas aeruginosaLeukocyte ElastasePeriplasmic Proteinsbiofilmsextracellular matrixPseudomonas aeruginosa

Identifiers

PMID29636440
PMCPMC5893882
OpenAlexW2797184297

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.