Evidence map›Paper›PMID 29636436›Full record

ArticlemBio2018

Broad-Spectrum Regulation of Nonreceptor Tyrosine Kinases by the Bacterial ADP-Ribosyltransferase EspJ.

Dominic J Pollard, Cedric N Berger, Ernest C So, Lu Yu, Kate Hadavizadeh, Patricia Jennings, Edward W Tate, Jyoti S Choudhary, Gad Frankel

Open access · goldAbstract read
In one paragraph

Article in mBio, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. EnteropathogenicInternational journal of molecular sciences · 2020
    Article
  6. Review
  7. Review
  8. Review
  9. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Dominic J PollardCentre for Molecular Microbiology and Infection, Department of Life Sciences, Imperial College, London United Kingdom, London, United Kingdom.
Cedric N BergerCentre for Molecular Microbiology and Infection, Department of Life Sciences, Imperial College, London United Kingdom, London, United Kingdom.ORCID 0000-0002-1316-5985
Ernest C SoCentre for Molecular Microbiology and Infection, Department of Life Sciences, Imperial College, London United Kingdom, London, United Kingdom.
Lu YuFunctional Proteomics Group, Chester Beatty Laboratories, Institute of Cancer Research, London, United Kingdom.
Kate HadavizadehDepartment of Chemistry, Imperial College, London United Kingdom, London, United Kingdom.
Patricia JenningsUniversity of California at San Diego, La Jolla, California, USA.
Edward W TateDepartment of Chemistry, Imperial College, London United Kingdom, London, United Kingdom.
Jyoti S ChoudharyFunctional Proteomics Group, Chester Beatty Laboratories, Institute of Cancer Research, London, United Kingdom.
Gad FrankelCentre for Molecular Microbiology and Infection, Department of Life Sciences, Imperial College, London United Kingdom, London, United Kingdom g.frankel@imperial.ac.uk.
Imperial College London · GBInstitute of Cancer Research · GBUniversity of California San Diego · US

Funding

Biotechnology and Biological Sciences Research CouncilMedical Research Council MR/K019007/1Medical Research Council MR/P028225/1Wellcome Trust 098051
6 · The paper itself

Abstract

Tyrosine phosphorylation is key for signal transduction from exogenous stimuli, including the defense against pathogens. Conversely, pathogens can subvert protein phosphorylation to control host immune responses and facilitate invasion and dissemination. The bacterial effectors EspJ and SeoC are injected into host cells through a type III secretion system by enteropathogenic and enterohemorrhagic

Indexed as

Host-Pathogen InteractionsADP Ribose TransferasesCell LineEnterobacteriaceaeHumansImmune EvasionProtein-Tyrosine KinasesADP Ribose TransferasesProtein-Tyrosine KinasesADP-ribosyltransferase toxinsCitrobacter rodentiuminfectionT3SS

Identifiers

PMID29636436
PMCPMC5893879
OpenAlexW2796604625

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.