Evidence map›Paper›PMID 29636430›Full record

ArticlemBio2018

Extracellular Electron Transfer Powers Enterococcus faecalis Biofilm Metabolism.

Damien Keogh, Ling Ning Lam, Lucinda E Doyle, Artur Matysik, Shruti Pavagadhi, Shivshankar Umashankar, Pui Man Low, Jennifer L Dale, Yiyang Song, Sean Pin Ng and 6 more

Erratum issuedAbstract read
In one paragraph

Article in mBio, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 67 papers.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed.

  1. Article
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  4. Science advances · 2026
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  5. Review
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  9. Insights into ecology, pathogenesis, and biofilm formation ofMicrobiology and molecular biology reviews : MMBR · 2025
    Review
  10. Genome-wide analysis ofJournal of bacteriology · 2025
    Article
  11. Role of sortase-assembled Ebp pili inMicrobiology spectrum · 2025
    Article
  12. Article
  13. Article
  14. Isolation and genomic analysis of "Applied and environmental microbiology · 2024
    Article
  15. Article
  16. Article
  17. The Impact ofPathogens (Basel, Switzerland) · 2024
    Review
  18. Article
  19. Article
  20. Diagnosis of extraintestinal pathogenicCurrent research in microbial sciences · 2024
    Review

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Damien Keogh *Singapore Centre for Environmental Life Science Engineering, Nanyang Technological University, Singapore.
Ling Ning Lam *Singapore Centre for Environmental Life Science Engineering, Nanyang Technological University, Singapore.
Lucinda E DoyleSingapore Centre for Environmental Life Science Engineering, Nanyang Technological University, Singapore.
Artur MatysikSingapore Centre for Environmental Life Science Engineering, Nanyang Technological University, Singapore.
Shruti PavagadhiSingapore Centre for Environmental Life Science Engineering, National University of Singapore, Singapore.
Shivshankar UmashankarSingapore Centre for Environmental Life Science Engineering, National University of Singapore, Singapore.
Pui Man LowSingapore Centre for Environmental Life Science Engineering, Nanyang Technological University, Singapore.
Jennifer L DaleDepartment of Microbiology, University of Minnesota Medical School, Minneapolis, Minnesota, USA.
Yiyang SongSingapore Phenome Center, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.
Sean Pin NgSingapore Phenome Center, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.
Chris B BoothroydSchool of Materials Science and Engineering, Nanyang Technological University, Singapore.
Gary M DunnyDepartment of Microbiology, University of Minnesota Medical School, Minneapolis, Minnesota, USA.
Sanjay SwarupSingapore Centre for Environmental Life Science Engineering, National University of Singapore, Singapore.
Rohan B H WilliamsSingapore Centre for Environmental Life Science Engineering, National University of Singapore, Singapore.
Enrico MarsiliSingapore Centre for Environmental Life Science Engineering, Nanyang Technological University, Singapore.
Kimberly A KlineSingapore Centre for Environmental Life Science Engineering, Nanyang Technological University, Singapore kkline@ntu.edu.sg.ORCID 0000-0002-5472-3074

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Enterococci are important human commensals and significant opportunistic pathogens. Biofilm-related enterococcal infections, such as endocarditis, urinary tract infections, wound and surgical site infections, and medical device-associated infections, often become chronic upon the formation of biofilm. The biofilm matrix establishes properties that distinguish this state from free-living bacterial cells and increase tolerance to antimicrobial interventions. The metabolic versatility of the enterococci is reflected in the diversity and complexity of environments and communities in which they thrive. Understanding metabolic factors governing colonization and persistence in different host niches can reveal factors influencing the transition to biofilm pathogenicity. Here, we report a form of iron-dependent metabolism for

Indexed as

Electron TransportBiofilmsEnergy MetabolismEnterococcus faecalisIronL-Lactate DehydrogenaseIronL-Lactate DehydrogenasebiofilmEnterococcus faecalisextracellular electron transferironmetabolism

Identifiers

PMID29636430
PMCPMC5893876

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.