Evidence map›Paper›PMID 29636345›Full record

ArticleCancer research2018

Enhanced Lymphodepletion Is Insufficient to Replace Exogenous IL2 or IL15 Therapy in Augmenting the Efficacy of Adoptively Transferred Effector CD8

C Bryce Johnson, Bennett R May, Brian P Riesenberg, Samantha Suriano, Shikhar Mehrotra, Elizabeth Garrett-Mayer, Mohamed L Salem, Emily K Jeng, Hing C Wong, Chrystal M Paulos and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in Cancer research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

C Bryce JohnsonDepartment of Surgery, Medical University of South Carolina, Charleston, South Carolina.
Bennett R MayDepartment of Surgery, Medical University of South Carolina, Charleston, South Carolina.
Brian P RiesenbergDepartment of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina.
Samantha SurianoDepartment of Surgery, Medical University of South Carolina, Charleston, South Carolina.
Shikhar MehrotraDepartment of Surgery, Medical University of South Carolina, Charleston, South Carolina.
Elizabeth Garrett-MayerDepartment of Public Health Sciences, Medical University of South Carolina, Charleston, South Carolina.
Mohamed L SalemImmunology and Biotechnology Division, Faculty of Science, Tanta University, Center of Excellence in Cancer Research, Tanta, Egypt.
Emily K JengAltor BioScience Corporation, Miramar, Florida.
Hing C WongAltor BioScience Corporation, Miramar, Florida.
Chrystal M PaulosDepartment of Surgery, Medical University of South Carolina, Charleston, South Carolina.
John M WrangleDepartment of Dermatology and Dermatological Surgery, Medical University of South Carolina, Charleston, South Carolina.
David J ColeDepartment of Surgery, Medical University of South Carolina, Charleston, South Carolina.
Mark P RubinsteinDepartment of Surgery, Medical University of South Carolina, Charleston, South Carolina. markrubinstein@musc.edu.
Medical University of South Carolina · US

Funding

Translational Science Laboratory Shared ResourceP30CA138313 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI RAYMOND N. DUBOIS · 2009 to 2026
$42.7M
TCR TRANSDUCED CDB T CELLS FOR ADOPTIVE IMMUNOTHERAPYP01CA154778 · NCI · LOYOLA UNIVERSITY CHICAGO · PI NISHIMURA, MICHAEL I. · 2011 to 2015
$15.4M
Mechanisms of durable antitumor immunity via CD26hiCD4+ T cellsR01CA208514 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI PAULOS, CHRYSTAL MARY · 2016 to 2020
$1.7M
Costimulatory mechanisms of antitumor Th17 cell immunityR01CA175061 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI PAULOS, CHRYSTAL MARY · 2013 to 2017
$1.5M
Maximizing Memory T Cell Responses by Matured Post Chemotherapy Dendritic CellsR01CA133503 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI RUBINSTEIN, MARK P · 2010 to 2012
$900k
Improving Adoptive T cell Therapy with ex vivo IL-12 Priming and LymphodepletionF30CA177208 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI JOHNSON, CHRISTOPHER BRYCE · 2013 to 2016
$156k
NCI NIH HHS F30 CA177208NCI NIH HHS P01 CA154778NCI NIH HHS P30 CA138313NCI NIH HHS R01 CA133503NCI NIH HHS R01 CA175061NCI NIH HHS R01 CA208514
6 · The paper itself

Abstract

Effector CD8

Indexed as

Adoptive TransferAnimalsCD8-Positive T-LymphocytesCell Line, TumorFemaleImmunotherapy, AdoptiveInterleukin-15Interleukin-2Lymphocyte ActivationLymphocyte DepletionMaleMiceMice, Inbred C57BLT-Lymphocytes, RegulatoryIL15 protein, humanIL2 protein, humanInterleukin-15Interleukin-2

Identifiers

PMID29636345
PMCPMC6108084
OpenAlexW2796602225

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.