Evidence map›Paper›PMID 29636181›Full record

ReviewMolecular immunology2019

Antigen processing and presentation in HIV infection.

Julie Boucau, Sylvie Le Gall

Open access · greenAbstract readReview
In one paragraph

Review in Molecular immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Protein-dependent CD4iScience · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Julie BoucauRagon Institute of MGH, MIT and Harvard, Cambridge, MA, 02139, United States.
Sylvie Le GallRagon Institute of MGH, MIT and Harvard, Cambridge, MA, 02139, United States. Electronic address: sylvie_legall@hms.harvard.edu.
Ragon Institute of MGH, MIT and Harvard · US

Funding

Regulation of CD8+ T cell immunity to tuberculosis (pending title)R01AI106725 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BEHAR, SAMUEL M · 2013 to 2022
$6.1M
Tuberculosis and T cell RecognitionR01AI123286 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BEHAR, SAMUEL M, FORTUNE, SARAH · 2016 to 2020
$3.5M
Mechanisms and optimization of epitope presentation by HIV-infectable cell subsetR01AI084753 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI LE GALL, SYLVIE · 2009 to 2013
$2.3M
Learning from attenuated CMV how to broaden HIV-specific T cell responsesR01AI112493 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI LE GALL, SYLVIE · 2014 to 2017
$2.2M
Immune responses against HIV-induced cell-derived neoepitopes and HIV controlR01AI084106 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI LE GALL, SYLVIE · 2009 to 2012
$2.1M
Defining and matching epitope presentation in HIV infection and vaccinationR56AI122947 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI LE GALL, SYLVIE · 2016 to 2016
$504k
The HLA-E peptidome in HIV infectionR21AI129717 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI LE GALL, SYLVIE · 2017 to 2018
$470k
Unbiased identification of HIV-derived antigens during latency and reactivationR21AI131912 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI LE GALL, SYLVIE · 2017 to 2018
$470k
NIAID NIH HHS R01 AI084106NIAID NIH HHS R01 AI084753NIAID NIH HHS R01 AI106725NIAID NIH HHS R01 AI112493NIAID NIH HHS R01 AI123286NIAID NIH HHS R21 AI129717NIAID NIH HHS R21 AI131912NIAID NIH HHS R56 AI122947
6 · The paper itself

Abstract

The presentation of virus-derived peptides by MHC molecules constitutes the earliest signals for immune recognition by T cells. In HIV infection, immune responses elicited during infection do not enable to clear infection and correlates of immune protection are not well defined. Here we review features of antigen processing and presentation specific to HIV, analyze how HIV has adapted to the antigen processing machinery and discuss how advances in biochemical and computational protein degradation analyses and in immunopeptidome definition may help identify targets for efficient immune clearance and vaccine immunogen design.

Indexed as

AIDS VaccinesAnimalsAntigen PresentationHistocompatibility AntigensHIV-1HIV InfectionsHumansAIDS VaccinesHistocompatibility AntigensHIVImmune escapeImmunopeptidomeProtein degradationT cellsVaccine immunogen design

Identifiers

PMID29636181
PMCPMC6174111
OpenAlexW2795851753

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.