ArticleMaterials science & engineering. C, Materials for biological applications2018
Effects of polycaprolactone on alendronate drug release from Mg-doped hydroxyapatite coating on titanium.
Article in Materials science & engineering. C, Materials for biological applications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed.
- Dual-action bisphosphonate hydrogel preserves cortical bone integrity and restores healing cascade in osteoporotic fracture-related infection.Nature communications · 2026Article
- Bisphosphonate-incorporated coatings for orthopedic implants functionalization.Materials today. Bio · 2023Review
- Fabrication and characterization of electrospun nanofibers using biocompatible polymers for the sustained release of venlafaxine.Scientific reports · 2022Article
- Design Strategies and Biomimetic Approaches for Calcium Phosphate Scaffolds in Bone Tissue Regeneration.Biomimetics (Basel, Switzerland) · 2022Review
- 3D-Printed Gentamicin-Releasing Poly-ε-Caprolactone Composite Prevents Fracture-RelatedPharmaceutics · 2022Article
- Advances of Hydroxyapatite Hybrid Organic Composite Used as Drug or Protein Carriers for Biomedical Applications: A Review.Polymers · 2022Review
- How Efficient are Alendronate-Nano/Biomaterial Combinations for Anti-Osteoporosis Therapy? An Evidence-Based Review of the Literature.International journal of nanomedicine · 2022Review
- Atomic Resolution Electron Microscopy: A Key Tool for Understanding the Activity of Nano-Oxides for Biomedical Applications.Nanomaterials (Basel, Switzerland) · 2021Article
- Nature-Inspired Unconventional Approaches to Develop 3D Bioceramic Scaffolds with Enhanced Regenerative Ability.Biomedicines · 2021Review
- Synthesis, Characterization, Antibacterial Properties, and In Vitro Studies of Selenium and Strontium Co-Substituted Hydroxyapatite.International journal of molecular sciences · 2021Article
- The Influence of Nanometals, Dispersed in the Electrophoretic Nanohydroxyapatite Coatings on the Ti13Zr13Nb Alloy, on Their Morphology and Mechanical Properties.Materials (Basel, Switzerland) · 2021Article
- Natural Antibiotic Oregano in Hydroxyapatite-Coated Titanium Reduces Osteoclastic Bone Resorption for Orthopedic and Dental Applications.ACS applied materials & interfaces · 2020Article
- Mechanical and Corrosion Properties of Laser Surface-Treated Ti13Nb13Zr Alloy with MWCNTs Coatings.Materials (Basel, Switzerland) · 2020Article
- Development of a long-acting direct-acting antiviral system for hepatitis C virus treatment in swine.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Natural Medicinal Compounds in Bone Tissue Engineering.Trends in biotechnology · 2020Review
- Substituted hydroxyapatite coatings of bone implants.Journal of materials chemistry. B · 2020Review
- Properties of Nanohydroxyapatite Coatings Doped with Nanocopper, Obtained by Electrophoretic Deposition on Ti13Zr13Nb Alloy.Materials (Basel, Switzerland) · 2019Article
- Effects of vitamin DRSC advances · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The scientific objective of this study was to understand the influence of PCL coating on alendronate drug release kinetics in vitro. Our hypothesis was PCL coating would minimize burst release of alendronate from plasma sprayed Mg-doped hydroxyapatite (HA) coated commercially pure titanium (CpTi) samples. In the US alone, over 44 million women and men aged 50 and older are affected by osteoporosis which can lead to replacement and/or revision surgeries. Alendronate is a widely-used drug for treating osteoporosis and would be an ideal drug to be loaded and released from these replacement systems. Initial burst release is a common phenomenon for the most drug loaded devices. To modulate the release kinetics, a biodegradable polymer, polycaprolactone (PCL), coating with slow degradable kinetics was employed. Samples with 2 and 4 wt% PCL showed about 34% and 26% release of alendronate within the first 24 h, respectively, compared to 75% burst release without any PCL coating. With the addition of a PCL coating, a controlled release kinetics of alendronate was achieved from HA coated titanium implants, which can potentially impact millions of patients worldwide having compromised bone due to osteoporosis.
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Registered trials
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