ArticlePediatric pulmonology2018
Children with severe acute asthma admitted to Dutch PICUs: A changing landscape.
Article in Pediatric pulmonology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Efficacy of a loading dose of IV salbutamol in children with severe acute asthma admitted to a PICU: a randomized controlled trial.European journal of pediatrics · 2022Trial
- Comparing Respiratory Support Modalities in Pediatric Asthma Exacerbation-A Systematic Review and Meta-Analysis.Pediatric reports · 2026Review
- Guided Inhalation via Electronic Monitoring in Children With Uncontrolled Asthma (the IMAGINE Study): Randomized Controlled Trial.JMIR pediatrics and parenting · 2025Article
- Near-fatal asthma in a 12-year-old girl leading to life-threatening tonsillar herniation: a case report.Journal of medical case reports · 2025Article
- Uncovering Non-Invasive Biomarkers in Paediatric Severe Acute Asthma Using Targeted Exhaled Breath Analysis.Metabolites · 2025Article
- Features of children with critical asthma hospitalized in a pediatric intensive care unit: Results from the ICU-3A study.Pediatric pulmonology · 2025Article
- Asthma in paediatric intensive care in England residents: observational study.Scientific reports · 2022Observational
- Quality of life and psychosocial outcomes in children with severe acute asthma and their parents.Pediatric pulmonology · 2020Article
- Risk factors for intensive care admission in children with severe acute asthma in the Netherlands: a prospective multicentre study.ERJ open research · 2020Article
- Extracorporeal and advanced therapies for progressive refractory near-fatal acute severe asthma in children.Pediatric pulmonology · 2020Review
- Current practices in children with severe acute asthma across European PICUs: an ESPNIC survey.European journal of pediatrics · 2020Article
- Population Pharmacokinetics of Intravenous Salbutamol in Children with Refractory Status Asthmaticus.Clinical pharmacokinetics · 2020Article
- Factors Associated with Failure of Intermittent Nebulization with Short-Acting Beta-Agonists in Children with Severe Asthma Exacerbation.Journal of asthma and allergy · 2020Article
- Continuous versus intermittent short-acting β2-agonists nebulization as first-line therapy in hospitalized children with severe asthma exacerbation: a propensity score matching analysis.Asthma research and practice · 2020Article
- A Loading Dose of IV Salbutamol in an Adolescent with Severe Acute Asthma and Cardiac Arrest.Case reports in pediatrics · 2019Article
- Children with severe acute asthma admitted to Dutch PICUs: A changing landscape.Pediatric pulmonology · 2018Article
- Nurse-driven Clinical Pathway Based on an Innovative Asthma Score Reduces Admission Time for Children.Pediatric quality & safetyArticle
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Authors and funding
11 authors.
Funding
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Abstract
The number of children requiring pediatric intensive care unit (PICU) admission for severe acute asthma (SAA) around the world has increased.
objectivesWe investigated whether this trend in SAA PICU admissions is present in the Netherlands.
methodsA multicenter retrospective cohort study across all tertiary care PICUs in the Netherlands. Inclusion criteria were children (2-18 years) hospitalized for SAA between 2003 and 2013. Data included demographic data, asthma diagnosis, treatment, and mortality.
resultsIn the 11-year study period 590 children (660 admissions) were admitted to a PICU with a threefold increase in the number of admissions per year over time. The severity of SAA seemed unchanged, based on the first blood gas, length of stay and mortality rate (0.6%). More children received highflow nasal cannula (P < 0.001) and fewer children needed invasive ventilation (P < 0.001). In 58% of the patients the maximal intravenous (IV) salbutamol infusion rate during PICU admission was 1 mcg/kg/min. However, the number of patients treated with IV salbutamol in the referring hospitals increased significantly over time (P = 0.005). The proportion of steroid-naïve patients increased from 35% to 54% (P = 0.004), with a significant increase in both age groups (2-4 years [P = 0.026] and 5-17 years [P = 0.036]).
conclusionsThe number of children requiring PICU admission for SAA in the Netherlands has increased. We speculate that this threefold increase is explained by an increasing number of steroid-naïve children, in conjunction with a lowered threshold for PICU admission, possibly caused by earlier use of salbutamol IV in the referring hospitals.
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