Evidence map›Paper›PMID 29635702›Full record

Observational studyNeurourology and urodynamics2018

Bowel function, sexual function, and symptoms of pelvic organ prolapse in women with and without urinary incontinence.

Anne P Cameron, Abigail R Smith, H Henry Lai, Catherine S Bradley, Alice B Liu, Robert M Merion, Brenda W Gillespie, Cindy L Amundsen, David Cella, James W Griffith and 10 more

Open access · bronzeAbstract readObservational Study
In one paragraph

Observational study in Neurourology and urodynamics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 36 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Sexual Health Behaviors by Age 17 and Lower Urinary Tract Symptoms at Age 19: PLUS Research Consortium Analysis of ALSPAC Data.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2023
    Article
  8. How Urinary Incontinence Affects Sexual Activity in Polish Women: Results from a Cross-Sectional Study.International journal of environmental research and public health · 2022
    Article
  9. Article
  10. Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 8 institutions in 1 country.

Anne P CameronUniversity of Michigan, Ann Arbor, Michigan.
Abigail R SmithArbor Research Collaborative for Heath, Ann Arbor, Michigan.
H Henry LaiWashington University School of Medicine, St. Louis, Missouri.ORCID 0000-0003-2691-994X
Catherine S BradleyCarver College of Medicine, University of Iowa, Iowa City, Iowa.
Alice B LiuUniversity of Washington, Seattle, Washington.
Robert M MerionArbor Research Collaborative for Heath, Ann Arbor, Michigan.
Brenda W GillespieUniversity of Michigan, Ann Arbor, Michigan.
Cindy L AmundsenDuke University, Durham, North Carolina.
David CellaFeinberg School of Medicine, Northwestern University, Chicago, Illinois.
James W GriffithFeinberg School of Medicine, Northwestern University, Chicago, Illinois.
Jonathan B WisemanArbor Research Collaborative for Heath, Ann Arbor, Michigan.
Karl J KrederDepartment of Urology, University of Iowa, Iowa City, Iowa.
Kimberly S KentonFeinberg School of Medicine, Northwestern University, Chicago, Illinois.
Margaret E HelmuthArbor Research Collaborative for Heath, Ann Arbor, Michigan.
Matthew O FraserDuke University, Durham, North Carolina.ORCID 0000-0003-3022-0015
J Quentin ClemensUniversity of Michigan, Ann Arbor, Michigan.
Ziya KirkaliNational Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland.
John W KusekNational Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland.
Nazema Y SiddiquiDuke University, Durham, North Carolina.
LURN Study GroupDuke University, Durham, North Carolina.
Arbor Research Collaborative for Health · USDuke University · USNorthwestern University · USUniversity of Michigan · USNational Institute of Diabetes and Digestive and Kidney Diseases · USUniversity of Iowa · USUniversity of Washington · USWashington University in St. Louis · US

Funding

Northwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8M
Continuation of the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) Data Coordinating CenterU24DK099879 · NIDDK · ARBOR RESEARCH COLLABORATIVE FOR HEALTH · PI GRAFF, JOHN JOSEPH · 2019 to 2025
$6.9M
Phenotype of urinary symptoms and relationships with genotype, sleep and obesityU01DK097779 · NIDDK · UNIVERSITY OF CHICAGO · PI GRIFFITH, JAMES WILLIAM, KENTON, KIMBERLY SUE · 2012 to 2025
$5.7M
Advancing the Measurement and Classification of Lower Urinary Tract DysfunctionU01DK097780 · NIDDK · DUKE UNIVERSITY · PI AMUNDSEN, CINDY, JELOVSEK, JOHN ERIC · 2012 to 2025
$5.3M
University of Iowa LURN Research SiteU01DK097772 · NIDDK · UNIVERSITY OF IOWA · PI BRADLEY, CATHERINE S, KREDER, KARL J · 2012 to 2025
$5.0M
Expansion of Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN)U01DK099879 · NIDDK · ARBOR RESEARCH COLLABORATIVE FOR HEALTH · PI MERION, ROBERT M · 2013 to 2018
$4.6M
University of Washington LURN Research SiteU01DK100011 · NIDDK · UNIVERSITY OF WASHINGTON · PI YANG, CLAIRE C · 2013 to 2025
$4.5M
University of Michigan LURN Research SiteU01DK099932 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CLEMENS, J. QUENTIN · 2013 to 2023
$4.4M
Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) Second Phase StudyU01DK100017 · NIDDK · WASHINGTON UNIVERSITY · PI LAI, HING HUNG HENRY · 2013 to 2025
$3.9M
Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN)Data CoordinatU01DK097776 · NIDDK · ARBOR RESEARCH COLLABORATIVE FOR HEALTH · PI MERION, ROBERT M · 2012 to 2016
$1.7M
Epigenomics in insulin resistance associated overactive bladderK23DK110417 · NIDDK · DUKE UNIVERSITY · PI SIDDIQUI, NAZEMA Y · 2017 to 2019
$567k
GENETIC ANALYSIS OF THE ACTIVATION OF A TYROSINE KINASEK08CA001422 · NCI · OREGON HEALTH AND SCIENCE UNIVERSITY · PI DRUKER, BRIAN J · 1990 to 1994
–
National Institute of Diabetes & Digestive & Kidney Diseases DK097772National Institute of Diabetes & Digestive & Kidney Diseases DK097776National Institute of Diabetes & Digestive & Kidney Diseases DK097779National Institute of Diabetes & Digestive & Kidney Diseases DK097780National Institute of Diabetes & Digestive & Kidney Diseases DK099879National Institute of Diabetes & Digestive & Kidney Diseases DK099932National Institute of Diabetes & Digestive & Kidney Diseases DK100011National Institute of Diabetes & Digestive & Kidney Diseases DK100017National Institutes of Health's National Center for Advancing Translational Sciences UL1TR001422NCATS NIH HHS UL1 TR001422NIDDK NIH HHS K23 DK110417NIDDK NIH HHS U01 DK097772NIDDK NIH HHS U01 DK097776NIDDK NIH HHS U01 DK097779NIDDK NIH HHS U01 DK097780NIDDK NIH HHS U01 DK099879NIDDK NIH HHS U01 DK099932NIDDK NIH HHS U01 DK100011NIDDK NIH HHS U01 DK100017NIDDK NIH HHS U24 DK099879Northwestern University
6 · The paper itself

Abstract

aimsBowel symptoms, pelvic organ prolapse, and sexual dysfunction are common, but their frequency among women with lower urinary tract symptoms (LUTS) has not been well described. Our aims were to describe pelvic floor symptoms among women with and without urinary incontinence (UI) and among subtypes of UI.

methodsWomen with LUTS seeking care at six U.S. tertiary care centers enrolled in prospective cohort study were studied. At baseline, participants completed the Pelvic Floor Distress Inventory (PFDI-20), Pelvic Organ Prolapse/Incontinence Sexual Questionnaire (PISQ-IR), and PROMIS GI Diarrhea, Constipation, and Fecal Incontinence Scales.

resultsMean age among the 510 women was 56.4 ± 14.4 years. Women who reported UI (n = 420) had more diarrhea and constipation symptoms (mean scores 49.5 vs 46.2 [P = 0.01] and 51.9 vs 48.4 [P < 0.01], respectively) at baseline. Among sexually active women, mean PISQ-IR subscale scores were lower among those with UI (condition specific: 89.8 vs 96.7, P < 0.01; condition impact: 79.8 vs 92.5, P < 0.01). Women with mixed urinary incontinence (MUI) (n = 240) reported more prolapse symptoms, fecal incontinence, and worse sexual function compared to those with stress urinary incontinence (SUI) and urgency urinary incontinence (UUI).

conclusionsWomen presenting with LUTS with UI reported significantly worse constipation, diarrhea, fecal incontinence, and sexual function compared to women without UI. In women with UI, sexual function and pelvic organ prolapse (POP) symptoms were worse in those with MUI compared to SUI and UUI.

Indexed as

AdultAgedConstipationDiarrheaFecal IncontinenceFemaleHumansLower Urinary Tract SymptomsMiddle AgedPelvic Organ ProlapseProspective StudiesSexual Dysfunction, PhysiologicalSurveys and QuestionnairesUnited StatesUrinary IncontinenceUrinary Incontinence, Stressconstipationfecal incontinencepelvic organ prolapseurinary incontinence

Identifiers

PMID29635702
PMCPMC6179951
OpenAlexW2796847346

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.