ArticleGenome biology and evolution2018
Selection in the Introgressed Regions of the Chimpanzee Genome.
Article in Genome biology and evolution, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 23 citations in OpenAlex.
- Local genetic adaptation to habitat in wild chimpanzees.Science (New York, N.Y.) · 2025Article
- Local genetic adaptation to habitat in wild chimpanzees.bioRxiv : the preprint server for biology · 2024Article
- Merging morphological and genetic evidence to assess hybridization in Western Eurasian late Pleistocene hominins.Nature ecology & evolution · 2022Article
- Population dynamics and genetic connectivity in recent chimpanzee history.Cell genomics · 2022Article
- Estimating bonobo (Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Divergence and introgression in small apes, the genus Hylobates, revealed by reduced representation sequencing.Heredity · 2021Article
- Current Progress in Evolutionary Comparative Genomics of Great Apes.Frontiers in genetics · 2021Review
- A fully integrated machine learning scan of selection in the chimpanzee genome.NAR genomics and bioinformatics · 2020Article
- Genetic Variation in Pan Species Is Shaped by Demographic History and Harbors Lineage-Specific Functions.Genome biology and evolution · 2019Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
During the demographic history of the Pan clade, there has been gene-flow between species, likely >200,000 years ago. Bonobo haplotypes in three subspecies of chimpanzee have been identified to be segregating in modern-day chimpanzee populations, suggesting that these haplotypes, with increased differentiation, may be a target of natural selection. Here, we investigate signatures of adaptive introgression within the bonobo-like haplotypes in chimpanzees using site frequency spectrum-based tests. We find evidence for subspecies-specific adaptations in introgressed regions involved with male reproduction in central chimpanzees, the immune system in eastern chimpanzees, female reproduction and the nervous system in Nigeria-Cameroon chimpanzees. Furthermore, our results indicate signatures of balancing selection in some of the putatively introgressed regions. This might be the product of long-term balancing selection resulting in a similar genomic signature as introgression, or possibly balancing selection acting on alleles reintroduced through gene flow.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.