Evidence map›Paper›PMID 29634937›Full record

ArticleDevelopmental cell2018

Coordination of Receptor Tyrosine Kinase Signaling and Interfacial Tension Dynamics Drives Radial Intercalation and Tube Elongation.

Neil M Neumann, Matthew C Perrone, Jim H Veldhuis, Robert J Huebner, Huiwang Zhan, Peter N Devreotes, G Wayne Brodland, Andrew J Ewald

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.

  1. Pooled it
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  5. Collective migration modes in development, tissue repair and cancer.Nature reviews. Molecular cell biology · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Neil M NeumannDepartment of Cell Biology and Center for Cell Dynamics, School of Medicine, Johns Hopkins University, 855 North Wolfe Street, Rangos 452, Baltimore, MD 21205, USA.
Matthew C PerroneDepartment of Civil and Environmental Engineering, University of Waterloo, Waterloo, ON N2L 3G1, Canada.
Jim H VeldhuisDepartment of Civil and Environmental Engineering, University of Waterloo, Waterloo, ON N2L 3G1, Canada.
Robert J HuebnerDepartment of Cell Biology and Center for Cell Dynamics, School of Medicine, Johns Hopkins University, 855 North Wolfe Street, Rangos 452, Baltimore, MD 21205, USA.
Huiwang ZhanDepartment of Cell Biology and Center for Cell Dynamics, School of Medicine, Johns Hopkins University, 855 North Wolfe Street, Rangos 452, Baltimore, MD 21205, USA.
Peter N DevreotesDepartment of Cell Biology and Center for Cell Dynamics, School of Medicine, Johns Hopkins University, 855 North Wolfe Street, Rangos 452, Baltimore, MD 21205, USA.
G Wayne BrodlandDepartment of Civil and Environmental Engineering, University of Waterloo, Waterloo, ON N2L 3G1, Canada; Centre for Bioengineering and Biotechnology, University of Waterloo, Waterloo, ON N2L 3G1, Canada.
Andrew J EwaldDepartment of Cell Biology and Center for Cell Dynamics, School of Medicine, Johns Hopkins University, 855 North Wolfe Street, Rangos 452, Baltimore, MD 21205, USA. Electronic address: andrew.ewald@jhmi.edu.
Johns Hopkins University · USUniversity of Waterloo · CAJohns Hopkins Medicine · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007309 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI COX, ANDREA L · 1985 to 2019
$43.2M
Excitable Networks in Directed Cell MigrationR35GM118177 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Peter N Devreotes · 2016 to 2026
$12.1M
The Role of Physical Cues in Collective Cell InvasionU54CA210173 · NCI · JOHNS HOPKINS UNIVERSITY · PI SUN, SEAN X · 2016 to 2020
$9.9M
Pathway Discovery and Target Validation for Outgrowth of Breast Cancer MetastasesU01CA217846 · NCI · JOHNS HOPKINS UNIVERSITY · PI BADER, JOEL S., EWALD, ANDREW JOSEF · 2017 to 2021
$4.8M
NCI NIH HHS U01 CA217846NCI NIH HHS U54 CA210173NIGMS NIH HHS R35 GM118177NIGMS NIH HHS T32 GM007309
6 · The paper itself

Abstract

We sought to understand how cells collectively elongate epithelial tubes. We first used 3D culture and biosensor imaging to demonstrate that epithelial cells enrich Ras activity, phosphatidylinositol (3,4,5)-trisphosphate (PIP

Indexed as

ActinsAnimalsCell MovementCell ProliferationCells, CulturedEpithelial CellsFemaleMammary Glands, AnimalMiceMice, TransgenicMorphogenesisras ProteinsSignal TransductionSurface TensionActinsras Proteinsbranching morphogenesiscell migrationcellular force inference toolkit (CellFIT)epithelial biologyfinite element modelinginterfacial tensionmammary glandmechanical signalingradial intercalation

Identifiers

PMID29634937
PMCPMC5983037
OpenAlexW2796527262

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.