Evidence map›Paper›PMID 29634739›Full record

ArticlePloS one2018

Metabolomic markers of fertility in bull seminal plasma.

Ana Luiza Cazaux Velho, Erika Menezes, Thu Dinh, Abdullah Kaya, Einko Topper, Arlindo Alencar Moura, Erdogan Memili

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed
15.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 118 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Ana Luiza Cazaux VelhoDepartment of Animal and Dairy Sciences, Mississippi State University, Mississippi State, MS, United States of America.
Erika MenezesDepartment of Animal and Dairy Sciences, Mississippi State University, Mississippi State, MS, United States of America.
Thu DinhDepartment of Animal and Dairy Sciences, Mississippi State University, Mississippi State, MS, United States of America.
Abdullah KayaAlta Genetic Inc., Watertown, WI, United States of America.
Einko TopperAlta Genetic Inc., Watertown, WI, United States of America.
Arlindo Alencar MouraDepartment of Animal Sciences, Federal University of Ceara, Fortaleza, Ceara, Brazil.
Erdogan MemiliDepartment of Animal and Dairy Sciences, Mississippi State University, Mississippi State, MS, United States of America.ORCID 0000-0002-8335-5645
Mississippi State University · USUniversidade Federal do Ceará · BRSelçuk University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metabolites play essential roles in biological systems, but detailed identities and significance of the seminal plasma metabolome related to bull fertility are still unknown. The objectives of this study were to determine the comprehensive metabolome of seminal plasma from Holstein bulls and to ascertain the potential of metabolites as biomarkers of bull fertility. The seminal plasma metabolome from 16 Holstein bulls with two fertility rates were determined by gas chromatography-mass spectrometry (GC-MS). Multivariate and univariate analyses of the data were performed, and the pathways associated with the seminal plasma metabolome were identified using bioinformatics approaches. Sixty-three metabolites were identified in the seminal plasma of all bulls. Fructose was the most abundant metabolite in the seminal fluid, followed for citric acid, lactic acid, urea and phosphoric acid. Androstenedione, 4-ketoglucose, D-xylofuranose, 2-oxoglutaric acid and erythronic acid represented the least predominant metabolites. Partial-Least Squares Discriminant Analysis (PLSDA) revealed a distinct separation between high and low fertility bulls. The metabolites with the greatest Variable Importance in Projection score (VIP > 2) were 2-oxoglutaric acid and fructose. Heat-map analysis, based on VIP score, and univariate analysis indicated that 2-oxoglutaric acid was less (P = 0.02); whereas fructose was greater (P = 0.02) in high fertility than in low fertility bulls. The current study is the first to describe the metabolome of bull seminal plasma using GC-MS and presented metabolites such as 2-oxoglutaric acid and fructose as potential biomarkers of bull fertility.

Indexed as

FertilityMetabolomicsAnimalsBiomarkersCattleMaleMetabolic Networks and PathwaysSemenBiomarkers

Identifiers

PMID29634739
PMCPMC5892889
OpenAlexW2797670585

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.