ArticleMenopause (New York, N.Y.)2018
Vascular dysfunction across the stages of the menopausal transition is associated with menopausal symptoms and quality of life.
Article in Menopause (New York, N.Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The association of vasomotor symptoms with fracture risk and bone mineral density in postmenopausal women: a systematic review and meta-analysis of observational studies.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024Pooled it
- The Effect of a Mindfulness-Based Stress Reduction (MBSR) Program on Quality of Life, Life Satisfaction, Sleep Quality, and Mental Well-Being in Menopausal Women: A Randomized Controlled Trial.Journal of nursing scholarship : an official publication of Sigma Theta Tau International Honor Society of Nursing · 2026Trial
- Effect of Exercise Modalities on Post-Exercise Hypotension in Normotensive Postmenopausal Women: A Randomized Controlled Trial on Vasomotor Symptoms Influence.European journal of sport science · 2025Trial
- Oxidative Stress and Inflammation Are Associated With Age-Related Endothelial Dysfunction in Men With Low Testosterone.The Journal of clinical endocrinology and metabolism · 2022Trial
- The severity of vasomotor symptoms and number of menopausal symptoms in postmenopausal women and select clinical health outcomes in the Women's Health Initiative Calcium and Vitamin D randomized clinical trial.Menopause (New York, N.Y.) · 2020Trial
- Sex comparisons across different indices of vascular health in recreationally active healthy adults.European journal of applied physiology · 2026Article
- Relations of Menopause Timing With Pressure Pulsatility in the Framingham Study.Hypertension (Dallas, Tex. : 1979) · 2026Article
- Age moderates the association between handgrip strength and large artery stiffness in women.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Article
- Physical activity moderates the relationship between hot flashes and arterial wave reflection in perimenopausal females.Physiological reports · 2026Article
- Menopausal Status and Thrombosis Risk in Hemodialysis Catheter Use: A Secondary Analysis of a Prospective Cohort.International journal of women's health · 2026Article
- Effect of Antihypertensive Losartan on CaJournal of cardiovascular development and disease · 2025Article
- Acute exogenous oestradiol augments endothelial and smooth muscle vasodilatory responsiveness in premenopausal but not postmenopausal females.The Journal of physiology · 2025Article
- Higher amounts of habitual physical activity changes the relationship between hot flashes and subclinical cardiovascular disease risk.Physiological reports · 2025Article
- Article
- Toward Blood-Based Precision Medicine: Identifying Age-Sex-Specific Vascular Biomarker Quantities on Circulating Vascular Cells.Cellular and molecular bioengineering · 2023Article
- Vasomotor symptoms and their links to cardiovascular disease risk.Current opinion in endocrine and metabolic research · 2023Article
- Association of Migraine and Vasomotor Symptoms.Mayo Clinic proceedings · 2023Article
- Beneficial Effects of Flaxseed and/or Mulberry Extracts Supplementation in Ovariectomized Wistar Rats.Nutrients · 2022Article
- Increased Risk of Cardio-Cerebrovascular Diseases in Migraine Patients: A Nationwide Population-Based, Longitudinal Follow-Up Study in South Korea.Journal of clinical neurology (Seoul, Korea) · 2022Article
- Menopausal symptoms and risk of heart failure: a retrospective analysis from Taiwan National Health Insurance Database.ESC heart failure · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
objectiveThe menopausal transition is associated with somatic symptoms and increased rates of depression, which can impair quality of life (QOL) and increase cardiovascular disease (CVD) risk. This period is also associated with accelerated vascular aging (arterial stiffening and endothelial dysfunction), an antecedent to CVD. This secondary analysis sought to explore associations between depression, menopausal symptoms and QOL, and vascular aging across menopause stages.
methodsArterial stiffness (carotid artery compliance), endothelial function (brachial artery flow-mediated dilation [FMD]), menopausal symptoms (Menopausal Symptom List [MSL]), depression (Center for Epidemiologic Studies Depression Scale [CES-D]), and QOL (Utian QOL Scale [UQOL]) were measured in 138 women (19-70 years) classified as premenopausal (n = 41, 34 ± 8 years; mean ± SD), early (n = 25, 49 ± 3 years), or late perimenopausal (n = 26, 50 ± 4 years), or early (n = 22, 55 ± 4 years) or late postmenopausal (n = 24, 61 ± 5 years). Differences across menopause stages were determined using one-way analysis of variance; associations between vascular measures and MSL, CES-D, and UQOL were tested using Pearson's correlation analyses.
resultsMenopausal symptoms, depression, and QOL worsened across menopause stages, particularly in late perimenopausal women. Vasosomatic symptom frequency, and general somatic symptom frequency and severity were inversely correlated with carotid artery compliance and FMD (r = -0.27 to -0.18, all P < 0.05). Only correlations with general somatic symptoms were significant after adjusting for multiple comparisons. Total QOL was positively correlated with carotid artery compliance (r = 0.23, P = 0.01). CES-D scores were not correlated with carotid artery compliance or FMD (r = -0.08, -0.03, P = 0.35).
conclusionsVascular dysfunction across the stages of menopause was associated with greater frequency and severity of menopausal symptoms, and lower QOL, but not depression. Mechanisms underlying these associations (eg, inflammation, oxidative stress) should be explored.
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