Evidence map›Paper›PMID 29634591›Full record

ArticleEpidemiology (Cambridge, Mass.)2018

Herpesvirus Infection in Infants with Gastroschisis.

Stephen S Francis, Joseph L Wiemels, Wei Yang, Gary M Shaw

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Epidemiology (Cambridge, Mass.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Re: Herpesvirus Infection in Infants with Gastroschisis.Epidemiology (Cambridge, Mass.) · 2019
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Stephen S FrancisFrom the Division of Epidemiology, School of Community Health Sciences, University of Nevada, Reno, NV.
Joseph L WiemelsHelen Diller Family Comprehensive Cancer Center and Department of Epidemiology and Biostatistics, University of California, San Francisco, CA.
Wei YangDepartment of Pediatrics, Neonatal and Developmental Medicine, Stanford University School of Medicine, Stanford, CA.
Gary M ShawDepartment of Pediatrics, Neonatal and Developmental Medicine, Stanford University School of Medicine, Stanford, CA.
UCSF Helen Diller Family Comprehensive Cancer Center · USUniversity of California, San Francisco · US

Funding

California Center of BD-STEPS - Finding Causes and Preventives of Birth DefectsU01DD001033 · DD · STANFORD UNIVERSITY · PI CARMICHAEL, SUZAN L, SHAW, GARY M · 2013 to 2017
$3.4M
NCBDD CDC HHS U01 DD001033
6 · The paper itself

Abstract

backgroundGastroschisis is a congenital malformation that has been shown to be more common in younger mothers and appears to be increasing in prevalence in the United States and elsewhere. Epidemiologic data suggest a potential role of infection and recent studies report an association between maternal antibodies to human herpesviruses (HHV) and development of gastroschisis.

methodsIn this study, we examined newborn bloodspots from 50 children with gastroschisis and 50 healthy controls using a highly sensitive digital droplet polymerase chain reaction assay covering eight human herpesviruses [herpes simplex sirus 1/2, Epstein-Barr virus (HHV-4), cytomegalovirus (HHV-5), HHV-6A/B, HHV-7, and HHV-8], to examine the presence of herpesvirus DNA at birth, which would suggest in utero infection.

resultsOne control tested positive for low-level cytomegalovirus infection. We found no evidence of an association between herpesvirus DNA in neonatal blood spots taken at birth and gastroschisis.

conclusionsOur results do not support direct involvement of herpesviruses in the etiology of gastroschisis. However, there are several limitations in our study, most notably the known induction of this congenital malformation early in pregnancy and our analysis of blood taken at birth. Therefore, we cannot conclude that herpesviruses play no role in the etiology of gastroschisis and further research is needed to better define this relationship.

Indexed as

CaliforniaCongenital AbnormalitiesGastroschisisHerpesviridaeHerpesviridae InfectionsHumansInfantPolymerase Chain ReactionPopulation Surveillance

Identifiers

PMID29634591
OpenAlexW2796509983

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.