ArticleBehavioural pharmacology2018
A behavioral economic analysis of the value-enhancing effects of nicotine and varenicline and the role of nicotinic acetylcholine receptors in male and female rats.
Article in Behavioural pharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 17 citations in OpenAlex.
- Effects of nicotinic receptor antagonism on nicotine and THC self-administration in a model of polysubstance use.The international journal of neuropsychopharmacology · 2026Article
- Effects of nicotinic receptor antagonism on nicotine and THC self-administration in a model of polysubstance use.bioRxiv : the preprint server for biology · 2025Article
- Pavlovian conditioning with the internal stimulus effects of intravenous nicotine heightens later nicotine taking with variation by dose and sex.Scientific reports · 2025Article
- Cholinergic regulation of decision making under risk of punishment.Neurobiology of learning and memory · 2025Article
- Nicotine addiction: More than just dopamine.Current opinion in neurobiology · 2023Review
- Elucidating the reinforcing effects of nicotine: a tribute to Nadia Chaudhri.Psychopharmacology · 2023Review
- Investigating sex differences and the effect of drug exposure order in the sensory reward-enhancing effects of nicotine and d-amphetamine alone and in combination.Neuropharmacology · 2022Article
- Reward-enhancing effects of d-amphetamine and its interactions with nicotine were greater in female rats and persisted across schedules of reinforcement.Behavioural pharmacology · 2021Article
- Nicotine-induced enhancement of a sensory reinforcer in adult rats: antagonist pretreatment effects.Psychopharmacology · 2021Article
- Varenicline rescues nicotine-induced decrease in motivation for sucrose reinforcement.Behavioural brain research · 2021Article
- The importance of acquisition learning on nicotine and varenicline drug substitution in a drug-discriminated goal-tracking task.Pharmacology, biochemistry, and behavior · 2020Article
- Sex Differences in the Reward-Enhancing Effects of Nicotine on Ethanol Reinforcement: A Reinforcer Demand Analysis.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2020Article
- Exploring the interoceptive stimulus effects of nicotine and varenicline.Pharmacology, biochemistry, and behavior · 2019Article
- Varenicline Targets the Reinforcing-Enhancing Effect of Nicotine on Its Associated Salient Cue During Nicotine Self-administration in the Rat.Frontiers in behavioral neuroscience · 2019Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Reinforcement value enhancement by nicotine of non-nicotine rewards is believed to partially motivate smoking behavior. Recently, we showed that the value-enhancing effects of nicotine are well characterized by reinforcer demand models and that the value-enhancing effects of the smoking-cessation aid bupropion (Zyban) are distinct from those of nicotine and differ between the sexes. The present study evaluated potential sex differences in the enhancement effects of nicotine and varenicline (Chantix) using a reinforcer demand methodology. The role of α4β2* and α7 nicotinic acetylcholine receptors (nAChRs) in the enhancing effects of nicotine and varenicline is also evaluated. Male and female rats (n=12/sex) were trained to lever press maintained by sensory reinforcement by visual stimulus (VS) presentations. Changes in the VS value following nicotine and varenicline administration were assessed using an established reinforcer demand approach. Subsequently, the effects of antagonism of α4β2* and α7 nAChRs on varenicline and nicotine-induced enhancement active lever-pressing were assessed using a progressive ratio schedule. Nicotine and varenicline enhanced VS demand equivalently between the sexes as evaluated by reinforcer demand. However, α4β2* receptor antagonism attenuated value enhancement by nicotine and varenicline in females, but only of nicotine in males.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.